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Pregled bibliografske jedinice broj: 625894

Structure-property relationship for cellular accumulation of macrolones in human polymorphonuclear leukocytes (PMNs)


Munić Kos, Vesna; Koštrun, Sanja; Fajdetić, Andrea; Bosnar, Martina; Kelnerić, Željko; Stepanić, Višnja; Eraković Haber, Vesna
Structure-property relationship for cellular accumulation of macrolones in human polymorphonuclear leukocytes (PMNs) // European journal of pharmaceutical sciences, 49 (2013), 2; 206-219 doi:10.1016/j.ejps.2013.02.019 (međunarodna recenzija, članak, znanstveni)


Naslov
Structure-property relationship for cellular accumulation of macrolones in human polymorphonuclear leukocytes (PMNs)

Autori
Munić Kos, Vesna ; Koštrun, Sanja ; Fajdetić, Andrea ; Bosnar, Martina ; Kelnerić, Željko ; Stepanić, Višnja ; Eraković Haber, Vesna

Izvornik
European journal of pharmaceutical sciences (0928-0987) 49 (2013), 2; 206-219

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Macrolone; macrolide; quinolone; cellular accumulation; polymorphonuclear leukocyte (PMN); structure–property relationship (SPR)

Sažetak
Macrolones are a new class of antimicrobial compounds consisting of a macrolide scaffold linked to a 4-quinolone-3-carboxylic acid moiety via C(4″) position of a macrolide. As macrolides are known to possess favorable pharmacokinetic properties by accumulating in inflammatory cells, in this study we determined the intensity of accumulation in human polymorphonuclear leukocytes (PMNs) of 57 compounds of the macrolone class and analyzed the relationship between the molecular structure and this cellular pharmacokinetic property. Accumulation of macrolones ranged from 0 to 5.5-fold higher than the standard macrolide azithromycin. Distinct structural features in all three considered molecule parts: the macrolide scaffold, quinolone moiety and the linker, affect cellular accumulation. Interestingly, while the parent macrolide, azithromycin, accumulates approximately 3-fold more than clarithromycin, among macrolones all clarithromycin derivatives accumulated in PMNs significantly more than their azithromycin counterparts. Modeling cellular accumulation of macrolones with simple molecular descriptors, as well as with the measured octanol–water distribution coefficient, revealed that the number of hydrogen bond donors and secondary amide groups negatively contribute to macrolone accumulation, while lipophilicity makes a positive contribution.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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