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Dibenzotetraaza[14]annulene – adenine conjugate recognizes complementary poly dT among ss-DNA / ss-RNA sequences


Radić Stojković, Marijana; Škugor, Marko; Tomić, Sanja; Grabar, Marina; Smrečki, Vilko; Dudek, Łukasz; Grolik, Jarosław; Eilmes, Julita; Piantanida, Ivo
Dibenzotetraaza[14]annulene – adenine conjugate recognizes complementary poly dT among ss-DNA / ss-RNA sequences // Organic & biomolecular chemistry, 11 (2013), 24; 4077-4085 doi:10.1039/c3ob40519b (međunarodna recenzija, članak, znanstveni)


Naslov
Dibenzotetraaza[14]annulene – adenine conjugate recognizes complementary poly dT among ss-DNA / ss-RNA sequences

Autori
Radić Stojković, Marijana ; Škugor, Marko ; Tomić, Sanja ; Grabar, Marina ; Smrečki, Vilko ; Dudek, Łukasz ; Grolik, Jarosław ; Eilmes, Julita ; Piantanida, Ivo

Izvornik
Organic & biomolecular chemistry (1477-0520) 11 (2013), 24; 4077-4085

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
DBTAA; DNA; RNA; thymine recognition; CD

Sažetak
Among three novel DBTAA derivatives only DBTAA-propyl-adenine conjugate 1 showed recognition of the consecutive oligo dT sequence by increased affinity and specific induced chirooptical response in comparison to other single stranded RNA and DNA ; whereby of particular importance is up until now unique efficient differentiation between dT and rU. At variance, its close analogue DBTAA-hexyl-adenine 2 did not reveal any selectivity among ss-DNA/RNA pointing out to the important role of steric factors (linker length) ; moreover non-selectivity of the reference compound (3, lacking adenine) stressed the importance of adenine interactions in the 1 selectivity.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Kemija



POVEZANOST RADA


Projekt / tema
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Ivo Piantanida, )
098-1191344-2860 - Proučavanje biomakromolekula računalnim metodama i razvoj novih algoritama (Sanja Tomić, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati