engleski

Identification of ABC Transporter Genes in Gonad Tissue of two Mediterranean Sea Urchin Species: Black, Arbacia lixula L., and Rocky, Paracentrotus lividus L.

MXR represents an important cellular detoxification mechanism in aquatic organisms as it provides them robustness toward natural and man-made xenobiotics. Several ABC transporters have the main roles in MXR phenotype – P-gp/ABCB1, MRP1-3/ABCC1-3, BCRP/ABCG2. This study identifies the presence of ABC transporters involved in MXR mechanism of Arbacia lixula and Paracentrotus lividus. AlABCB1/Pgp, AlABCC3/MRP3, AlABCC9/SUR- like ; AlABCG-like transcripts were identified in A. lixula and PlABCC1/P-gp, PlABCC3/MRP3, PlABCC5/MRP5, PlABCC9/SUR-like in P. lividus. For each of new partial sequences we performed detailed phylogenetic and identity analysis 29 as a first step toward full characterization and understanding of MXR in these Mediterranean sea urchin species.

ABC transporters; MXR mechanism; Arbacia lixula; Paracentrotus lividus

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