Nodal marginal zone lymphoma in a patient with antiphospholipid syndrome (CROSBI ID 595833)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Matušan Ilijaš, Koviljka ; Grahovac, Blaženka ; Pećanić, Sanja ; Naćinović Duletić Antica ; Novak, Srđan ; Lučin, Ksenija ; Jonjić, Nives
engleski
Nodal marginal zone lymphoma in a patient with antiphospholipid syndrome
Antiphospholipid syndrome (APS) is a disorder mediated by the characteristic antiphospholipid antibodies with subsequent arterial and venous thromboembolic incidents. There is increasing evidence of an association between autoimmune events on the one side and lymphoproliferative disorders on the other side. The association of APS and splenic marginal zone lymphoma is recognized, but according to our knowledge the association with nodal marginal zone lymphoma so far has not yet been documented. We present the case of 64-year old female with abnormal coagulation test that was admitted to the Clinical Hospital Centre Rijeka for a surgical excision of slow growing tumor mass of the left femoral region. Pathological analysis of surgical specimen revealed an increased lymph node measuring 4 cm in greatest dimension. Histological, immunohistochemical and molecular analysis confirmed a diagnosis of nodal marginal zone non- Hodgkin lymphoma (NHL), while serological test revealed the presence of lupus anticoagulants and anticardiolipin antibodies while antinuclear antibodies were negative. Activated partial thromboplastin time as well as factor V, VII and X was reduced. This case is presenting a synchronous appearance of a specific type of non-Hodgkin lymphoma and antiphospholipid syndrome. So, it highlights the importance of targeted diagnostic processing of NHL patient with coagulation disorder in order to exclude the possibly associated APS.
antiphospholipid syndrome; lymphoma; B-cell; marginal zone; gene rearrangement; B-lymphocyte
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Podaci o prilogu
2012.
objavljeno
Podaci o matičnoj publikaciji
21. Ljudevit Jurak internacionalni simpozij komparativne patologije : knjiga sažetaka
Podaci o skupu
Ljudevit Jurak Internacionalni simpozij komparativne patologije (21 ; 2012)
poster
01.06.2012-02.06.2012
Zagreb, Hrvatska