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Inhibition of acetylcholinesterase by three new pyridinium compounds and their effect on phosphorylation of the enzyme


Škrinjarić-Špoljar, Mira; Burger, Nicoletta; Buntić, Anđelka
Inhibition of acetylcholinesterase by three new pyridinium compounds and their effect on phosphorylation of the enzyme // Technical program, CB Medical Treatment Symposium: An Exploration of Present Capabilities and Future Requirements for Chemical and Biological Medical Treatment, Abstracts of Platform and Poster Presentations, The Second Chemical and Biological Medical Treatment Symposium, Spiez, Švicarska, 1996 / Price, Barbara (ur.).
Spiez, Švicarska: NC-Laboratory Spiez, Švicarska, 1996. (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Inhibition of acetylcholinesterase by three new pyridinium compounds and their effect on phosphorylation of the enzyme

Autori
Škrinjarić-Špoljar, Mira ; Burger, Nicoletta ; Buntić, Anđelka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Technical program, CB Medical Treatment Symposium: An Exploration of Present Capabilities and Future Requirements for Chemical and Biological Medical Treatment, Abstracts of Platform and Poster Presentations, The Second Chemical and Biological Medical Treatment Symposium, Spiez, Švicarska, 1996 / Price, Barbara - Spiez, Švicarska : NC-Laboratory Spiez, Švicarska, 1996

Skup
The Second Chemical and Biological Medical Treatment Symposium

Mjesto i datum
Spiez, Švicarska, 07.-12. 07. 1996

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
acetylcholinesterase; pyridinium compounds; reversible inhibition; VX; Soman; protection of acetylcholinesterase in phosphorylation

Sažetak
The reversible inhibition of acetylcholinesterase (AChE) was measured against acetylthiocholine as substrate with: 1 phenacyl-2-methylpyridinium chloride, 1-benzoylethylpyridinium chloride and 1-benzoylethylpyridinium-4-aldoxime chloride. The enzyme/inhibitor dissociation constants for binding the inhibitor to the catalytic and/or allosteric binding sites on the enzyme were evaluated and the binding affinity of the compounds compared to their protective effect in AChE inhibition by soman and VX.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
00220104

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb

Citiraj ovu publikaciju

Škrinjarić-Špoljar, Mira; Burger, Nicoletta; Buntić, Anđelka
Inhibition of acetylcholinesterase by three new pyridinium compounds and their effect on phosphorylation of the enzyme // Technical program, CB Medical Treatment Symposium: An Exploration of Present Capabilities and Future Requirements for Chemical and Biological Medical Treatment, Abstracts of Platform and Poster Presentations, The Second Chemical and Biological Medical Treatment Symposium, Spiez, Švicarska, 1996 / Price, Barbara (ur.).
Spiez, Švicarska: NC-Laboratory Spiez, Švicarska, 1996. (poster, međunarodna recenzija, sažetak, znanstveni)
Škrinjarić-Špoljar, M., Burger, N. & Buntić, A. (1996) Inhibition of acetylcholinesterase by three new pyridinium compounds and their effect on phosphorylation of the enzyme. U: Price, B. (ur.)Technical program, CB Medical Treatment Symposium: An Exploration of Present Capabilities and Future Requirements for Chemical and Biological Medical Treatment, Abstracts of Platform and Poster Presentations, The Second Chemical and Biological Medical Treatment Symposium, Spiez, Švicarska, 1996.
@article{article, editor = {Price, B.}, year = {1996}, pages = {17}, keywords = {acetylcholinesterase, pyridinium compounds, reversible inhibition, VX, Soman, protection of acetylcholinesterase in phosphorylation}, title = {Inhibition of acetylcholinesterase by three new pyridinium compounds and their effect on phosphorylation of the enzyme}, keyword = {acetylcholinesterase, pyridinium compounds, reversible inhibition, VX, Soman, protection of acetylcholinesterase in phosphorylation}, publisher = {NC-Laboratory Spiez, \v{S}vicarska}, publisherplace = {Spiez, \v{S}vicarska} }