engleski

Inhibition of acetylcholinesterase by three new pyridinium compounds and their effect on phosphorylation of the enzyme

The reversible inhibition of acetylcholinesterase (AChE) was measured against acetylthiocholine as substrate with: 1 phenacyl-2-methylpyridinium chloride, 1-benzoylethylpyridinium chloride and 1-benzoylethylpyridinium-4-aldoxime chloride. The enzyme/inhibitor dissociation constants for binding the inhibitor to the catalytic and/or allosteric binding sites on the enzyme were evaluated and the binding affinity of the compounds compared to their protective effect in AChE inhibition by soman and VX.

acetylcholinesterase; pyridinium compounds; reversible inhibition; VX; Soman; protection of acetylcholinesterase in phosphorylation

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