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Pregled bibliografske jedinice broj: 624528

Molecular dynamics based studies on human DPP III revealed determinants for its broad substrate selectivity


Tomić, Sanja; Tomić, Antonija; Gonzalez, Miguel
Molecular dynamics based studies on human DPP III revealed determinants for its broad substrate selectivity // IRENE – 'In Silico Enzyme Sesign and Screening'
Trst, Italija, 2012. (predavanje, međunarodna recenzija, sažetak, znanstveni)


Naslov
Molecular dynamics based studies on human DPP III revealed determinants for its broad substrate selectivity

Autori
Tomić, Sanja ; Tomić, Antonija ; Gonzalez, Miguel

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
IRENE – 'In Silico Enzyme Sesign and Screening'

Mjesto i datum
Trst, Italija, 07-09.05.2012

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Dipeptidylpeptidase III; molecular modelling

Sažetak
Dipeptidylpeptidase III (DPP III) is a zinc-exopeptidase which hydrolyses a number of biologically active peptides (e.g., endomorphin1, endomorphin2 and enkephalin), and also some synthetics substrates, e.g., ArgArg2naphthylamide (RRNA), by cleaving dipeptides sequentially from their N termini. Because of its physiological as well pathophysiological roles (contribution in the protein catabolism, regulatory role in the pain-modulatory system, and enhanced level of DPP III was found in several carcinoma). In order to find determinants for its broad specificity for peptides of varying lengths and composition, we performed a series of MD simulations based on studies on human DPP III and its complexes with different substrates.

Izvorni jezik
Engleski

Znanstvena područja
Fizika



POVEZANOST RADA


Projekt / tema
098-1191344-2860 - Proučavanje biomakromolekula računalnim metodama i razvoj novih algoritama (Sanja Tomić, )

Ustanove
Institut "Ruđer Bošković", Zagreb