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Pregled bibliografske jedinice broj: 623657

The Arg72Pro Polymorphism of TP53 in Croatian Population


Zorić, Arijana; Horvat, Anđela; Balija, Melita; Slade, Neda
The Arg72Pro Polymorphism of TP53 in Croatian Population // Croatica chemica acta, 85 (2012), 2; 239-243 doi:10.5562/cca1866 (međunarodna recenzija, članak, znanstveni)


Naslov
The Arg72Pro Polymorphism of TP53 in Croatian Population

Autori
Zorić, Arijana ; Horvat, Anđela ; Balija, Melita ; Slade, Neda

Izvornik
Croatica chemica acta (0011-1643) 85 (2012), 2; 239-243

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Tumor suppressor gene p53; p73; SNP; Arg72Pro

Sažetak
Single nucleotide polymorphisms of TP53 gene in human populations are expected to cause perturbation of p53 function, and therefore could influence risk and/or progress of disease. There are differences in inducing apoptosis, cell cycle arrest, transcriptional activity, protein interactions between variants in codon 72 (Arg72Pro), although the association of polymorphism and risk of cancer is controversial. The aim of our study was to investigate the frequency of alleles and genotypes of Arg72Pro polymorphism in the ethnically homogenous Croatian population and to compare it with the worldwide populations. In a cohort of 576 participants the genotype frequencies of Arg/Arg, Arg/Pro and Pro/Pro are 54.34, 38.71 and 6.95 %, respectively. We statistically sorted the population of Croatia into the same group with other European populations and Caucasians from North America. This finding is important for the molecular pathways studies involved in disease as well as in pharmacogenetic studies.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2391 - Uloga mreže proteina p53/p73 u sarkomima mekih tkiva čovjeka (Neda Slade, )
108-0000000-3435 - Genetika, priroda i epidemiologija značajnijih živčanih i mišićnih bolesti (ŽMB) (Nina Canki-Klain, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Hrvatski zavod za transfuzijsku medicinu

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Uključenost u ostale bibliografske baze podataka:


  • Chemical Abstracts
  • Science Citation Index
  • Cambridge Structural Database System (CSD System)
  • Chemical Titles


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