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Pregled bibliografske jedinice broj: 621909

Protumor effects of proinflammatory mediators in breast cancer


Sirotković-Skerlev, Maja; Kulić, Ana; Bradić, Lada; Čačev, Tamara
Protumor effects of proinflammatory mediators in breast cancer // Periodicum biologorum, 114 (2012), 4; 489-496 (međunarodna recenzija, pregledni rad, znanstveni)


Naslov
Protumor effects of proinflammatory mediators in breast cancer

Autori
Sirotković-Skerlev, Maja ; Kulić, Ana ; Bradić, Lada ; Čačev, Tamara

Izvornik
Periodicum biologorum (0031-5362) 114 (2012), 4; 489-496

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Breast cancer ; cytokines ; chemokines

Sažetak
Inflammation is defined as an enabling characteristic of malignant growth. Many proinflammatory mediators have protumor capabilities. In this review we focus on the protumor effect of cytokines and chemokines in breast cancer. We discuss the role of interleukin 1β, interleukin 6, tumor necrosis factor α, CCL2, CCL5, and CXCL12 and its receptor CXCR4 as typical mediators implicated in breast cancer progression. We also analyze the impact of transcription factor NF-κB. Proinflammatory mediators with protumor effects should be considered as therapeutic targets in breast cancer. It is challenging how to find optimal anti-cytokine and anti-chemokine regiments as a part of anticancer therapy.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2508 - Molekularna genetika i farmakogenetika gastrointestinalnih tumora (Sanja Kapitanović, )
108-1080058-0046 - KARCINOM DOJKE-MOLEKULARNE,GENETSKE I KLINIČKE KARAKTERISTIKE (Damir Vrbanec, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus