Effects of Alpha-MSH on Corneal Epithelial Lesions in Rats (CROSBI ID 191302)
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Podaci o odgovornosti
Pavan, Josip ; Lukenda, Adrian ; Štambuk, Nikola ; Konjevoda, Paško ; Kaštelan, Snježana ; Ćurković, Marko.
engleski
Effects of Alpha-MSH on Corneal Epithelial Lesions in Rats
We investigated the influence of alpha-melanocyte stimulating hormone (alpha-MSH) on the healing of corneal epithelial lesions in male Wistar rats. The lesions were induced by abrading corneal epithelium with a surgical lancet under a biomicroscope. Before the abrasion corneal epithelium was softened with 40% ethanol. Alpha-MSH drops in a concentration of 1×10–4 mg/mL significantly promoted epithelial healing, when compared to the control group treated with 0.9% NaCl. Significant reduction of ocular irritation was also observed. Topical alpha-MSH medication could promote the healing of corneal wounds and reduce local inflammatory response without the major side effects of the corticosteroid therapy.
alpha-MSH ; cornea ; drops ; epithelization ; wound ; healing ; irritation
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Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti