engleski

Efficacy of 5-fluorouracil, interferon, and albothyl in the treatment of hrHPV-related or unrelated cervical intraepithelial neoplasia

problem statement: Comparison of different treatment approaches and different cofactors on the outcome of the therapy of cervical intraepithelial neoplasia (CIN) in the presence/absence of high risk human papilloma virus (hrHPV) and bacterial/yeast infections was presented. Patients: 45 patients in the age range from 18-64 years diagnosed with CIN were included in the study. Methods: 15 patients without hrHPV were treated with albothyl. Other 30 patients was randomly divided into two subgroups and treated either by 5-fluorouracil or interferon. Results were evaluated by Canonical correlation analysis, Multiple regression, General regression model and odds ratio. Results: In the 22.2 % of the patients total clearance and in 48.9 % of them lower grade lesions were observed. Clearance of hrHPV was found in 93.3 % of the patients. There was no significant difference among three types of therapy. Conclusion: CIN and hrHPV were highly associated with age, presence of bacterial infection and number of births, while outcome of the therapy was controlled by the type of contraception rather than by the type of therapy.

bacterial infection; noninvasive methods; treatment modalities; viral infection; yeast infection

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