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Pregled bibliografske jedinice broj: 621039

Association of TNF-α and PTPN22 SNPs with the risk and clinical outcome of type 1 diabetes


Popović Hadžija, Marijana; Korolija, Marina; Vukadinović, Gabrijela; Hadžija, Mirko
Association of TNF-α and PTPN22 SNPs with the risk and clinical outcome of type 1 diabetes // Central european journal of biology, 8 (2013), 513-519 doi:10.2478/s11535-013-0166-5 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 621039 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Association of TNF-α and PTPN22 SNPs with the risk and clinical outcome of type 1 diabetes

Autori
Popović Hadžija, Marijana ; Korolija, Marina ; Vukadinović, Gabrijela ; Hadžija, Mirko

Izvornik
Central european journal of biology (1895-104X) 8 (2013); 513-519

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
polymorphism; autoimmunity; cytokine;

Sažetak
Type 1 Diabetes mellitus (T1DM) begins with aberrant inflammatory process followed by auto-destruction in genetically susceptible individuals. Therefore, we hypothesized that gain-of-function allelic variants TNF-α -238A, -308A and PTPN22 1858T could be associated not only with T1DM development but also with the clinical outcome in patients of Bosnia and Herzegovina. A total of 402 subjects were enrolled in the association study. SNPs were determined by PCR-RFLP. Data was analyzed by GraphPad Prism and Sigma Stat 3.5 software. Genotypes frequencies at TNF-α -238 and -308 loci were not statistically different between patients and controls. In contrast, distribution of genotypes at 1858 position of PTPN22 was significantly different, due to higher frequency of gain-of-function gene variants in patients than controls. Moreover, long term glucose regulation (based on HbA1c level) was significantly worse in patients with the risk TNF-α-308A allele than in patients with non-risk (G) allele. However, patients with the risk allele of both genes (TNF-α-308A and PTPN22 1858T) had the worst glycemic control, suggesting that those two work synergistically. In conclusion, in population of Bosnia and Herzegovina TNF-α-308A allele is significantly associated with the worse long-term glucose control, but PTPN22 1858T allele is significantly associated with diabetes development.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
098-0982464-2460 - Dobivanje struktura nalik Langerhansovim otočićima iz matičnih stanica miša (Hadžija, Mirko, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Popović Hadžija, Marijana; Korolija, Marina; Vukadinović, Gabrijela; Hadžija, Mirko
Association of TNF-α and PTPN22 SNPs with the risk and clinical outcome of type 1 diabetes // Central european journal of biology, 8 (2013), 513-519 doi:10.2478/s11535-013-0166-5 (međunarodna recenzija, članak, znanstveni)
Popović Hadžija, M., Korolija, M., Vukadinović, G. & Hadžija, M. (2013) Association of TNF-α and PTPN22 SNPs with the risk and clinical outcome of type 1 diabetes. Central european journal of biology, 8, 513-519 doi:10.2478/s11535-013-0166-5.
@article{article, year = {2013}, pages = {513-519}, DOI = {10.2478/s11535-013-0166-5}, keywords = {polymorphism, autoimmunity, cytokine, }, journal = {Central european journal of biology}, doi = {10.2478/s11535-013-0166-5}, volume = {8}, issn = {1895-104X}, title = {Association of TNF-α and PTPN22 SNPs with the risk and clinical outcome of type 1 diabetes}, keyword = {polymorphism, autoimmunity, cytokine, } }
@article{article, year = {2013}, pages = {513-519}, DOI = {10.2478/s11535-013-0166-5}, keywords = {polymorphism, autoimmunity, cytokine, }, journal = {Central european journal of biology}, doi = {10.2478/s11535-013-0166-5}, volume = {8}, issn = {1895-104X}, title = {Association of TNF-α and PTPN22 SNPs with the risk and clinical outcome of type 1 diabetes}, keyword = {polymorphism, autoimmunity, cytokine, } }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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