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Pregled bibliografske jedinice broj: 620937

Viral inhibition of BAK promotes murine cytomegalovirus dissemination to salivary glands


Handke, W.; Luig, C.; Popović, Branka; Krmpotić, Astrid; Jonjić, Stipan; Brune, W.
Viral inhibition of BAK promotes murine cytomegalovirus dissemination to salivary glands // Journal of Virology, 87 (2013), 6; 3592-3596 doi:10.1128/JVI.02657-12 (međunarodna recenzija, članak, znanstveni)


Naslov
Viral inhibition of BAK promotes murine cytomegalovirus dissemination to salivary glands

Autori
Handke, W. ; Luig, C. ; Popović, Branka ; Krmpotić, Astrid ; Jonjić, Stipan ; Brune, W.

Izvornik
Journal of Virology (0022-538X) 87 (2013), 6; 3592-3596

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cytomegalovirus; BAK; apoptosis

Sažetak
Apoptosis induction is an important host defense mechanism to control viral infection, which is antagonized by viral proteins. Murine cytomegalovirus m41.1 encodes a viral inhibitor of BAK oligomerization (vIBO) that blocks the mitochondrial apoptosis mediator BAK. However, its importance for viral fitness in vivo has not been investigated. Here, we show that an m41.1-deficient virus attains reduced titers in salivary glands of wild-type but not Bak1−/− mice, indicating a requirement of BAK inhibition for optimal dissemination in vivo.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Stipan Jonjić, )
062-0621261-1268 - Uloga imunosubverzivnih citomegalovirusnih gena u latenciji (Astrid Krmpotić, )

Ustanove
Medicinski fakultet, Rijeka

Profili:

Avatar Url Astrid Krmpotić (autor)

Avatar Url Stipan Jonjić (autor)

Avatar Url Branka Popović (autor)

Citiraj ovu publikaciju

Handke, W.; Luig, C.; Popović, Branka; Krmpotić, Astrid; Jonjić, Stipan; Brune, W.
Viral inhibition of BAK promotes murine cytomegalovirus dissemination to salivary glands // Journal of Virology, 87 (2013), 6; 3592-3596 doi:10.1128/JVI.02657-12 (međunarodna recenzija, članak, znanstveni)
Handke, W., Luig, C., Popović, B., Krmpotić, A., Jonjić, S. & Brune, W. (2013) Viral inhibition of BAK promotes murine cytomegalovirus dissemination to salivary glands. Journal of Virology, 87 (6), 3592-3596 doi:10.1128/JVI.02657-12.
@article{article, year = {2013}, pages = {3592-3596}, DOI = {10.1128/JVI.02657-12}, keywords = {cytomegalovirus, BAK, apoptosis}, journal = {Journal of Virology}, doi = {10.1128/JVI.02657-12}, volume = {87}, number = {6}, issn = {0022-538X}, title = {Viral inhibition of BAK promotes murine cytomegalovirus dissemination to salivary glands}, keyword = {cytomegalovirus, BAK, apoptosis} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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