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Pregled bibliografske jedinice broj: 620332

Genotype-independent decrease in plasma dopamine beta-hydroxylase activity in Alzheimer's disease


Mustapić, Maja; Presečki, Paola; Pivac, Nela; Mimica, Ninoslav; Hof, Patrick R.; Šimić, Goran; Folnegović Šmalc, Vera; Muck-Seler, Dorotea
Genotype-independent decrease in plasma dopamine beta-hydroxylase activity in Alzheimer's disease // Progress in neuro-psychopharmacology & biological psychiatry, 44 (2013), 94-99 doi:10.1016/j.pnpbp.2013.02.002 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 620332 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Genotype-independent decrease in plasma dopamine beta-hydroxylase activity in Alzheimer's disease

Autori
Mustapić, Maja ; Presečki, Paola ; Pivac, Nela ; Mimica, Ninoslav ; Hof, Patrick R. ; Šimić, Goran ; Folnegović Šmalc, Vera ; Muck-Seler, Dorotea

Izvornik
Progress in neuro-psychopharmacology & biological psychiatry (0278-5846) 44 (2013); 94-99

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Alzheimer’s disease; Cognitive decline; dopamine beta-hydroxylase; DBH gene polymorphisms; plasma DBH activity

Sažetak
The noradrenergic system is involved in the etiology and progression of Alzheimer’s disease (AD) but its role is still unclear. Dopamine beta-hydroxylase (DBH) as a catecholamine-synthesizing enzyme plays a central role in noradrenaline (NA) synthesis and turnover. Plasma DBH (pDBH) activity shows wide inheritable interindividual variability that is under genetic control. The aim of this study was to determine pDBH activity, DBH (C-970T ; rs1611115) and DBH (C1603T ; rs6271) gene polymorphisms in 207 patients with AD and in 90 healthy age-matched controls. Plasma DBH activity was lower, particularly in the early stage of AD, compared to values in middle and late stages of the disease, as well as to control values. Two-way ANOVA revealed significant effect of both diagnosis and DBH (C-970T) or DBH (C1603T) genotypes on pDBH activity, but without significant diagnosis x genotype interaction. No association was found between AD and DBH C-970T (OR = 1.08, 95% CI 1.13-4.37 ; p = 0.779) and C1603T (OR = 0.89 ; 95% CI 0.36-2.20 ; p = 0.814) genotypes controlled for age, gender, and ApoE4 allele. The decrease in pDBH activity, found in early phase of AD suggests that alterations in DBH activity represent a compensatory mechanism for the loss of noradrenergic neurons, and that treatment with selective NA reuptake inhibitors may be indicated in early stages of AD to compensate for loss of noradrenergic activity in the locus coeruleus.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
098-0982522-2455 - Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja (Pivac, Nela, MZOS ) ( POIROT)
098-0982522-2457 - Farmakogenomika i proteomika serotoninskog i kateholaminskog sustava (Muck-Šeler, Dorotea, MZOS ) ( POIROT)
108-1081870-2418 - BAP, shizoafektivni poremećaj,shizofrenija:Različite bolesti ili kontinuum? (Folnegović-Šmalc, Vera, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
Psihijatrijska bolnica "Sveti Ivan" Zagreb

Citiraj ovu publikaciju

Mustapić, Maja; Presečki, Paola; Pivac, Nela; Mimica, Ninoslav; Hof, Patrick R.; Šimić, Goran; Folnegović Šmalc, Vera; Muck-Seler, Dorotea
Genotype-independent decrease in plasma dopamine beta-hydroxylase activity in Alzheimer's disease // Progress in neuro-psychopharmacology & biological psychiatry, 44 (2013), 94-99 doi:10.1016/j.pnpbp.2013.02.002 (međunarodna recenzija, članak, znanstveni)
Mustapić, M., Presečki, P., Pivac, N., Mimica, N., Hof, P., Šimić, G., Folnegović Šmalc, V. & Muck-Seler, D. (2013) Genotype-independent decrease in plasma dopamine beta-hydroxylase activity in Alzheimer's disease. Progress in neuro-psychopharmacology & biological psychiatry, 44, 94-99 doi:10.1016/j.pnpbp.2013.02.002.
@article{article, year = {2013}, pages = {94-99}, DOI = {10.1016/j.pnpbp.2013.02.002}, keywords = {Alzheimer’s disease, Cognitive decline, dopamine beta-hydroxylase, DBH gene polymorphisms, plasma DBH activity}, journal = {Progress in neuro-psychopharmacology and biological psychiatry}, doi = {10.1016/j.pnpbp.2013.02.002}, volume = {44}, issn = {0278-5846}, title = {Genotype-independent decrease in plasma dopamine beta-hydroxylase activity in Alzheimer's disease}, keyword = {Alzheimer’s disease, Cognitive decline, dopamine beta-hydroxylase, DBH gene polymorphisms, plasma DBH activity} }
@article{article, year = {2013}, pages = {94-99}, DOI = {10.1016/j.pnpbp.2013.02.002}, keywords = {Alzheimer’s disease, Cognitive decline, dopamine beta-hydroxylase, DBH gene polymorphisms, plasma DBH activity}, journal = {Progress in neuro-psychopharmacology and biological psychiatry}, doi = {10.1016/j.pnpbp.2013.02.002}, volume = {44}, issn = {0278-5846}, title = {Genotype-independent decrease in plasma dopamine beta-hydroxylase activity in Alzheimer's disease}, keyword = {Alzheimer’s disease, Cognitive decline, dopamine beta-hydroxylase, DBH gene polymorphisms, plasma DBH activity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • BIOSIS Previews (Biological Abstracts)
  • EMBASE (Excerpta Medica)
  • MEDLINE


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