engleski

Endogenously labeled thyroid hormones (131I-T3/T4) in sera of patients with differentiated thyroid carcinoma

Patients with differentiated thyroid carcinoma (DTC), who have undergone thyroidectomy and radioablation with iodine (131-I), are usually monitored with ultrasonography (US) of the neck, 131-I whole body scan (WBS), and determination of thyroglobulin (tg) concentrations in serum. A chomatographic method (CHROM) designed for detection of in vivo labeled thyroid hormones (131I-T3/T4), that circulate in the body after administration of 131-I for a WBS, may be used in monitoring of these patients. This study included 35 patients with DTC. US, and the CHROM method were performed for each of them. Although this preliminary study included a small number of patients, we show that the CHROM method can be useful as an additional test in monitoring of patients with DTC, especially those with discordant WBS nad Tg results.

thyroid carcinoma ; neck ultrasonography ; iodine-131 ; whole-body scintigraphy ; chromatography

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