engleski

Capsaicin significantly reduces sinonasal polyps

Some reports indicate that topical nasal capsaicin treatment, usually effective in reducing symptoms of vasomotor rhinitis, may reduce symptoms in patients with nasal polyps. Objective: to investigate the effect of topical capsaicin treatment in severe sinonasal polyposis. Nine non--allergic, non--asthmatic patients with diffuse eosinophilic nasal polyposis were subjected to topical capsaicin treatment regimen: for 3 consecutive days 0, 5 ccm of 30 mumol/L capsaicin solution sprayed in each nostril, and 100 mumol/L capsaicin solution on days 4 and 5 respectively. Coronary CT images were made shortly before the treatment. Baseline nasal lavages, and a questionnaire containing subjective symptoms and nasal endosocpy were taken just prior to the first application. Nasal lavages were performed prior to and after the last treatment and in 4 weeks, endoscopy and subjective scores at each week visit, and correspondent CT scans 4 weeks after the treatment. CT images were analysed by computer calculating the the nose/sinuses air volume (NSAV) from the surface of aerated parts of nasal and sinus cavities for each slice per patient prior to and after treatment. Statistical analysis was performed comparing NSAV, subjective scores, endoscopy scores and ECP levels in nasal lavages prior to and after treatment. Results. Topical treatment with capsaicin significantly increased NSAV, very significantly improved subjective and endoscopy scores, but did not alter ECP levels in nasal lavages significantly.

CT scores; diffuse nasal polyposis; topical capsaicin; subjective scores; ECP

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