engleski

Thyroid cancer in clinical thyroid diseases register of university Hospital "sestre milosrdnice".

The aim of our research is to make an analysis of the hospital population through the period of eighteen years (1980-1997) and to calculate representation of the thyroid cancer in that sample. We were interested in histological representation, sex distribution with female to male ratio (F/M), average age at diagnosis, presence of metastasis at diagnosis and the size of the tumor. Following the representation of the follicular carcinoma through the years we wanted to discover possible abnormalities of the daily iodine uptake at the examined population. Separovic et al. claim that in areas without endemic goiter representation of the follicular carcinoma among malignant tumors is 5 to 15% while in the areas without an endemic goiter representation is up to 40%. At the same time we have started creating the computer register supplemented with a clinical data for further following of the thyroid cancer. Our intention was to add part of the database in computer system "Thanatos" that relates to malignant diseases in the Department of clinical pathology "Ljudevit Jurak" to the hospital's Central Register for Cancer. Biopsy materials were acquired after partial or total thyreoidectomias of the patients that were worked on in University hospital" Sestre milosrdnice ". Materials were embedded in paraffin wax, cutted in slice 5 um thick, colored with hemalaun-eosin and analyzed with microscope. Pathology specialists analyzed all materials. During the eighteen years period (1980-1997) at the Department of clinical pathology "Ljudevit Jurak", University hospital "Sestre milosrdnice" in Zagreb, there have been total of 196 878 biopsy findings. We have separated pathohistologycal diagnosis of the thyroid cancer. There have been total of 379 thyroid cancer biopsy findings. We have found 219 (57, 8% of all cancer) papillary carcinoma, 77 (20, 3%) follicular carcinoma, 29 (7, 7%) medullar carcinoma, 30 (7, 9%) anaplastic carcinoma and on category other 24 (6, 3%) of all thyroid cancer. Findings by other categories of our interest were as follows: papillary carcinoma had female to male ratio 3, 38:1, metastasis in 26% an average size 1, 78 cm (0, 73-3, 83). Female to male ratio in follicular carcinoma was 2, 21:1, metastasis in 9, 1% and average size 2, 86 cm (1, 5- 5). Medullar carcinomas average size was 2, 29 cm (0, 5-4), metastasis in 51, 7 % and F/M ratio 1, 42:1. F/M ratio for anaplastic carcinoma was 1, 73:1, average size 2, 75 cm (1, 5-5) and presence of metastasis in 33, 3%. Average age was for papillary carcinoma 45, 4 years, for follicular cancer 51, 1 yr., medullar carcinoma 50, 7 yr. and anaplastic carcinoma 55, 6 yr. Among all of the thyroid cancer, there has been one difference observed. Average age of the patients with papillary carcinoma (45, 4 yr.) is greater than quoted in literature. The representation of the follicular carcinoma among malignant tumors according to values quoted in literature is 5-15 % in areas without an endemic goiter. The representation in our sample is 20, 3% and it is in correlation with presence of the endemic goiter in Croatia. Our result suggests further research. Other results are in correlation with the literature.

thyroid cancer; thyroid diseases; registry

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