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Comparison of in vivo and in vitro prostaglandin E2 production by squamous cell carcinoma of the head and neck

Prostaglandin E(2) has been identified as an immunosuppressive factor in patients with squamous cell carcinoma of the head and neck. Spontaneous prostaglandin E(2) production by 21 cancer cell lines, which were obtained from 17 patients with squamous cell carcinoma of the head and neck, was determined by radioimmunoassay. In comparison with normal keratinocyte cultures, prostaglandin E(2) production by cancer cell lines was significantly decreased (P < 0.0001). Prostaglandin E(2) levels demonstrated no correlation to the site, stage, or histopathologic differentiation of the tumor. In a separate group of 17 patients with squamous cell carcinoma of the head and neck, tumor cells were isolated from fresh tumor specimens, and 24-hour PGE(2) production in vitro was assayed. No correlation was found with tumor site, stage, or 5-year disease-free survival. Although prostaglandin E(2) may have biologic significance in vivo in patients with squamous cell carcinoma of the head and neck, these findings suggest that measurements of tumor cell-derived prostaglandin E(2) are not predictive of biologic behavior.

arachidonic acid; prostaglandin E2; by squamous cell carcinoma of the head and neck

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