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Correlation of tumor size using CT and CYFRA 21-1 level in NSCLC patients.

The aim of the research is to determine the correlation between the level of tumor marker CYFRA 21-1 and the diameter of non-small cell lung cancer (NSCLC) measuerd by computed tomography (CT). It is hypothesized that greater tumor masses contain more cells in apoptosis, so the associated level of CYFRA 21-1 is going to be higher. The study population includes 164 subjects with NSCLC, 52 with lung metastases and 30 with benign lung cysts. The measurement of CYFRA 21-1 level is performed by electrochemiluminescence immunoassay, and the measurement of the biggest diameter of NSCLC, lung metastases and benign lung cysts is done by CT. Obtained data are statistically analysed. The subjects with greater tumor diameter and stage of NSCLC had a significantly higher level of CYFRA 21-1 unlike groups with lung metastases and cysts that lack such correlation. CYFRA 21-1 showed a high sensitivity in NSCLC of 74, 0%. NSCLC can be separated from the other groups by measurement of blood level of cytokreatin 19 soluble fragments.

Non small cell lung cancer; tumor markers; Cyfra 21-1; apoptosis; computet tomography; lung neoplasms

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