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Macrolactonolides: a novel class of anti- inflammatory compounds


Tomašković, Linda; Komac, Marijana; Makaruha Stegić, Oresta; Munić, Vesna; Ralić, Jovica; Stanić, Barbara; Banjanac, Mihailo; Marković, Stribor; Hrvačić, Boška; Čipčić Paljetak, Hana et al.
Macrolactonolides: a novel class of anti- inflammatory compounds // Bioorganic & medicinal chemistry, 21 (2013), 1; 321-332 doi:10.1016/j.bmc.2012.10.036 (međunarodna recenzija, članak, znanstveni)


Naslov
Macrolactonolides: a novel class of anti- inflammatory compounds

Autori
Tomašković, Linda ; Komac, Marijana ; Makaruha Stegić, Oresta ; Munić, Vesna ; Ralić, Jovica ; Stanić, Barbara ; Banjanac, Mihailo ; Marković, Stribor ; Hrvačić, Boška ; Čipčić Paljetak, Hana ; Padovan, Jasna ; Glojnarić, Ines ; Eraković Haber, Vesna ; Mesić, Milan ; Merćep, Mladen

Izvornik
Bioorganic & medicinal chemistry (0968-0896) 21 (2013), 1; 321-332

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Concept; anti-inflammatory; glucocorticoid; macrolides

Sažetak
New concept in design of safe glucocorticoid therapy was introduced by conjugating potent glucocorticoid steroids with macrolides (macrolactonolides). These compounds were synthesized from various steroid 17β-carboxylic acids and 9a-N-(3-aminoalkyl) derivatives of 9- deokso- 9a-aza-9a-homoeritromicin A and 3- descladinosyl-9- deokso-9a-aza-9a-homoeritromicin A using stable alkyl chain. Combining property of macrolides to preferentially accumulate in immune cells, especially in phagocyte cells, with anti- inflammatory activity of classic steroids, we designed molecules which showed good anti- inflammatory activity in ovalbumin (OVA) induced asthma in rats. The synthesis, in vitro and in vivo anti- inflammatory activity of this novel class of compounds are described.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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