engleski

Thrombocyte serotonin and serum cholesterol in depressed patients

Introduction Numerous studies have confirmed the connection of reduced serum cholesterol and thrombocyte serotonin concentration with suicidal behavior in psychiatric patients. Materials and methods In accordance to ICD-10, 55 depressed patients with suicide attempt and 77 depressed patients with no suicide attempt were separated in two subgroups ; F32.2 and F33.2. Control group was presented by the healthy blood donors. The fasting serum cholesterol concentration was established using standard enzymatic method, while the thrombocyte serotonin concentration was determined by ELISA method. Results The ANOVA test (N= 228, Fratio=8.26, p<0.001) found significant difference of cholesterol concentration, with lowest concentration in the group of depressed patients with attempted suicide, diagnoses F32.2 (p=0.031) and F33.2 (p=0.011), compared to the group of depressed patients without attempted suicides. Upon gender stratification, the significance remained for the female patients (ANOVA, N=125, Fratio=6.06, p=0.003). The thrombocyte serotonin was found to be significantly different in all groups (SNK post hoc test, p<0.05, N=187, Fratio=37.69, p<0.001), with the lowest thrombocyte serotonin in the group of depressed patients with no suicide attempt (F32.2), compared to the same diagnosis with suicide attempt (MW-test, p=0.018). The same significance was found for the group of female (ANOVA, N=103, Fratio =11.81, p<0.001) and male patients (ANOVA, N=84, Fratio=30.40, p<0.001). Conclusion In the group of depressed patients with attempted suicide, lower serum cholesterol values have been confirmed. In the group of depressed patients with no suicide attempt, lower values of thrombocyte serotonin have been confirmed, presumably as the response to the psychopharmacological therapy.

thrombocyte serotonin; cholesterol; depression

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