Napredna pretraga

Pregled bibliografske jedinice broj: 616119

Dissection of the antiviral NK cell response by MCMV mutants


Jonjić, Stipan; Krmpotić, Astrid; Arapović, Jurica; Koszinowski, U.H.
Dissection of the antiviral NK cell response by MCMV mutants // Methods in molecular biology, 415 (2008), 127-149 doi:10.1007/978-1-59745-570-1_8 (međunarodna recenzija, članak, znanstveni)


Naslov
Dissection of the antiviral NK cell response by MCMV mutants

Autori
Jonjić, Stipan ; Krmpotić, Astrid ; Arapović, Jurica ; Koszinowski, U.H.

Izvornik
Methods in molecular biology (1064-3745) 415 (2008); 127-149

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
NK cells; MCMV

Sažetak
Our understanding of virus control by natural killer (NK) cells relies mainly on in vitro observations. The significance of these findings for virus control in vivo is not yet fully understood. Complexity is added by the fact that many viruses, particularly herpesviruses, are equipped with sets of genes that, dependent on the genetic background of the host, modify the NK cell response. The advent of recombinant DNA technology and mutagenesis procedures for BAC-cloned viral genomes has made it possible not only to screen for viral proteins with such functions but also to assess their biological relevance. Mutant viruses with gene defects reveal the efficacy and complexity of NK cell control. Here, we describe procedures to assess the NK cell response to mouse cytomegalovirus (MCMV), a prominent virus model for studying NK cell functions in vivo.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
ISBN 978-1-58829-746-4.



POVEZANOST RADA


Projekt / tema
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Stipan Jonjić, )

Ustanove
Medicinski fakultet, Rijeka

Profili:

Avatar Url Astrid Krmpotić (autor)

Avatar Url Stipan Jonjić (autor)

Avatar Url Jurica Arapović (autor)

Citiraj ovu publikaciju

Jonjić, Stipan; Krmpotić, Astrid; Arapović, Jurica; Koszinowski, U.H.
Dissection of the antiviral NK cell response by MCMV mutants // Methods in molecular biology, 415 (2008), 127-149 doi:10.1007/978-1-59745-570-1_8 (međunarodna recenzija, članak, znanstveni)
Jonjić, S., Krmpotić, A., Arapović, J. & Koszinowski, U. (2008) Dissection of the antiviral NK cell response by MCMV mutants. Methods in molecular biology, 415, 127-149 doi:10.1007/978-1-59745-570-1_8.
@article{article, year = {2008}, pages = {127-149}, DOI = {10.1007/978-1-59745-570-1\_8}, keywords = {NK cells, MCMV}, journal = {Methods in molecular biology}, doi = {10.1007/978-1-59745-570-1\_8}, volume = {415}, issn = {1064-3745}, title = {Dissection of the antiviral NK cell response by MCMV mutants}, keyword = {NK cells, MCMV} }

Časopis indeksira:


  • Scopus
  • MEDLINE


Citati