Innate immunity to cytomegalovirus in the murine model (CROSBI ID 47542)
Prilog u knjizi | ostalo
Podaci o odgovornosti
Vidal, Silvia ; Krmpotić, Astrid ; Pyzik, Michal ; Jonjić, Stipan
engleski
Innate immunity to cytomegalovirus in the murine model
Cells of the innate immune system, including macrophages, DCs and NK cells play an important role in the control of viral infection before the induction of a specific immune response, of which generation they are also crucial. The infection of mice with MCMV as a model of HCMV infection has been particularly informative in elucidating the role of innate and adaptive immune response mechanisms during infection. NK cells are considered the most important effector cells in early CMV surveillance. An evolutionary struggle between NK cells and CMVs can be inferred from the existence of a broad range of viral mechanisms designed to compromise NK-cell function. This chapter describes major innate immune response mechanisms involved in control of MCMV, with an emphasis on NK-cell mediated viral detection as well as virally-encoded immune evasion mechanisms.
innate immunity, cytomegalovirus, murine model
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Podaci o prilogu
192-214.
objavljeno
Podaci o knjizi
Cytomegaloviruses : from molecular pathogenesis to intervention
Reddehase, Matthias
Caister Academic Press
2013.
978-1-908230-18-8