A study of photodegradation of drug rosuvastatin calcium in solid state and solution under UV and visible light irradiation : The influence of certain dyes as efficient stabilizers (CROSBI ID 189862)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Litvić, Mladen ; Šmic, Karolina ; Vinković, Vladimir ; Filipan-Litvić, Mirela
engleski
A study of photodegradation of drug rosuvastatin calcium in solid state and solution under UV and visible light irradiation : The influence of certain dyes as efficient stabilizers
Photodegradation of rosuvastatin calcium (1) under several radiation wavelengths in solid state and solution in solvents of different polarity has been studied. It was shown that 1 is very sensitive, especially in solution, even to low energy wavelengths and main and almost exclusive degradation pathway includes formation of diastereomeric dihydrophenanthrene derivatives (R, S, R)-2 and (S, S, R)-2. Absolute configurations of isolated diastereomeric photoproducts in forms of respective lactones 3 and 4 have been determined. First partial diastereoselective photocyclization of 1 leading 10.5% d.e. of (R, S, R)-2 over (S, S, R)-2 has been determined in water as a solvent. To prevent photodegradation of 1 in solution use of brown glass is necessary. Solid formulations of 1 are efficiently protected against photodegradation by the presence of combination of dyes such as yellow iron oxide and pink color E122 or beta-carotene inside the formulation or tablet coating.
rosuvastatin calcium; photodegradation; dihydrophenanthrene; diastereoselectivity; photoprotection
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Podaci o izdanju
252
2013.
84-92
objavljeno
1010-6030
10.1016/j.jphotochem.2012.11.008