engleski

Paget's disease as a cause of severe paraplegia, with complete recovering after alendronate therapy: case report.

We report a clinical case of unusual clinical and radiological features of Paget's disease in a 42-year old, previously healthy Caucasian woman who suffered of severe paraplegia. The patient was treated daily with 10 mg alendronate and 0.25 mcg calcitriol. Six months later the patient was able to stand up and after eight months complete recovery has been achieved. Subsequent analyses indicated: normalization of bone turnover, less osteoplastic foci on x-ray images of vertebrae and pelvis, regression of hyperosification in areas of vertebrae Th XI and Th XII on NMR images and improved mobility of the patient.

Paget's disease; severe paraplegia; alendronate therapy

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