Inactivation of cholinesterases by silver and gold ions in vitro (CROSBI ID 189418)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Vinković Vrček, Ivana ; Šinko, Goran
engleski
Inactivation of cholinesterases by silver and gold ions in vitro
The main goal of the present study was to investigate the effects of silver and gold ions on cholinesterases (ChEs) activity due to increasing application of these metals in a wide variety of nanomaterials. A chromogenic assay using the substrate o-nitrophenyl acetate/butyrate made it possible to conclude unmistakably that both metals inhibit ChEs. Addition of bovine serum albumin (BSA) indicates that binding of metal ions to albumin could serve to scavenge metals and consequently reduce their amount for reaction with ChEs. The effects of metal ions on ChE should be taken into consideration when using this enzyme as an environmental biomarker.
acetylcholinesterase; butyrylcholinesterase; silver; gold; Inhibition
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Podaci o izdanju
11 (6)
2013.
935-944
objavljeno
1895-1066
1644-3624
10.2478/s11532-013-0225-4
Povezanost rada
Kemija, Javno zdravstvo i zdravstvena zaštita