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Inactivation of cholinesterases by silver and gold ions in vitro (CROSBI ID 189418)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Vinković Vrček, Ivana ; Šinko, Goran Inactivation of cholinesterases by silver and gold ions in vitro // Central European journal of chemistry, 11 (2013), 6; 935-944. doi: 10.2478/s11532-013-0225-4

Podaci o odgovornosti

Vinković Vrček, Ivana ; Šinko, Goran

engleski

Inactivation of cholinesterases by silver and gold ions in vitro

The main goal of the present study was to investigate the effects of silver and gold ions on cholinesterases (ChEs) activity due to increasing application of these metals in a wide variety of nanomaterials. A chromogenic assay using the substrate o-nitrophenyl acetate/butyrate made it possible to conclude unmistakably that both metals inhibit ChEs. Addition of bovine serum albumin (BSA) indicates that binding of metal ions to albumin could serve to scavenge metals and consequently reduce their amount for reaction with ChEs. The effects of metal ions on ChE should be taken into consideration when using this enzyme as an environmental biomarker.

acetylcholinesterase; butyrylcholinesterase; silver; gold; Inhibition

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Podaci o izdanju

11 (6)

2013.

935-944

objavljeno

1895-1066

1644-3624

10.2478/s11532-013-0225-4

Povezanost rada

Kemija, Javno zdravstvo i zdravstvena zaštita

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