engleski

Cytogenetic consequences after occupational exposure to antineoplastic drugs

Cytogenetic monitoring was carried out on a group of 38 nurses who reconstitute antineoplastic drugs in order to determine the extent of chromosomal damage. Genotoxic activities of antineoplastic drugs are studied by chromosome aberration assay, micronucleus assay, sister chromatid exchange SCE frequency high frequency cells HFC analysis, and mitotic activity of peripheral lymphocytes. Results confirmed that occupational exposure to a mixture of antineoplastic drugs may cause genome damages. The results of this study show that biomonitoring after exposure to a mixture of antineoplastic drugs which express clastogenic and aneugenic activity should involve a battery of cytogenetic methods.

antineoplastic drug ; biomonitoring ; chromosome aberration ; SCE ; micronucleus assay ; mitotic activity ; smoking ; occupational exposure

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