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Pregled bibliografske jedinice broj: 609342

Polymorphisms in the IL-18 and IL-12B genes and their association with the clinical outcome in Croatian patients with Type 1 diabetes


Popović Hadžija, Marijana; Korolija, Marina; Jemin, Nikolina; Pavković, Iva; Pavković, Pajica; Pape Medvidović, Edita; Hadžija, Mirko
Polymorphisms in the IL-18 and IL-12B genes and their association with the clinical outcome in Croatian patients with Type 1 diabetes // Gene, 512 (2013), 2; 477-481 doi:10.1016/j.gene.2012.10.02 (međunarodna recenzija, kratko priopcenje, znanstveni)


CROSBI ID: 609342 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Polymorphisms in the IL-18 and IL-12B genes and their association with the clinical outcome in Croatian patients with Type 1 diabetes

Autori
Popović Hadžija, Marijana ; Korolija, Marina ; Jemin, Nikolina ; Pavković, Iva ; Pavković, Pajica ; Pape Medvidović, Edita ; Hadžija, Mirko

Izvornik
Gene (0378-1119) 512 (2013), 2; 477-481

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
diabetes; Interleukin; age at onset; glycated hemoglobin
(diabetes; Interleukin; age at onset; gGlycated hemoglobin)

Sažetak
Genetic variants of IL-18 and IL-12B may be important in immunoregulatory abnormalities, observed in the patients with Type 1 diabetes mellitus (T1DM), that contribute to individual differences in response to a treatment. Therefore, we examined the significance of IL-18-137G/C, IL- 18-607C/A, and IL-12B A/C polymorphisms in Croatians (187 patients, 236 controls), not only as factors that contribute to susceptibility to T1DM, but also as determinants of the clinical presentation of disease. The polymorphism screening has been performed using PCR sequence- specific primers (IL-18) or PCR-RFLP (IL-12B) approach. Results were evaluated by GraphPad Prism and Sigma Stat 3.5, Arlequin software and calculator for Hardy–Weinberg equilibrium. The genotype, allele and haplotype distribution were not statistically different between the patients and control subjects. The clinical parameter analysis revealed that patients with minor alleles at each locus, IL-18-137C/-607A, were significantly younger at T1DM onset than carriers of major alleles, IL-18-137G/ -607C (20 vs 23.5 years). Moreover, the concomitant presence of minor alleles not only of IL-18 but also of IL- 12B, is associated with the risk of disease progression even at younger age. These patients developed diabetes at 16 years of age, what is significantly earlier (p=0.044) compared to 25.5 years of age in patients with common alleles IL- 18-137G/-607C/IL-12B A. Furthermore, combined genotype analysis of IL-18 and IL-12B has pointed out that patients with CC/AA/AA genotype have the worst glucose control based on HbA1c (8.7%, range 6.8–13.1%). In conclusion, susceptibility to T1DM in Croatians is not strongly associated with IL- 18-137/-607 and IL-12B polymorphisms. These SNPs are associated with the higher risk of earlier disease development and might be implicated in the effectiveness of glycemic control.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
098-0982464-2460 - Dobivanje struktura nalik Langerhansovim otočićima iz matičnih stanica miša (Hadžija, Mirko, MZOS ) ( POIROT)

Ustanove:
Klinika za dijabetes, endokrinologiju i bolesti metabolizma Vuk Vrhovac,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Popović Hadžija, Marijana; Korolija, Marina; Jemin, Nikolina; Pavković, Iva; Pavković, Pajica; Pape Medvidović, Edita; Hadžija, Mirko
Polymorphisms in the IL-18 and IL-12B genes and their association with the clinical outcome in Croatian patients with Type 1 diabetes // Gene, 512 (2013), 2; 477-481 doi:10.1016/j.gene.2012.10.02 (međunarodna recenzija, kratko priopcenje, znanstveni)
Popović Hadžija, M., Korolija, M., Jemin, N., Pavković, I., Pavković, P., Pape Medvidović, E. & Hadžija, M. (2013) Polymorphisms in the IL-18 and IL-12B genes and their association with the clinical outcome in Croatian patients with Type 1 diabetes. Gene, 512 (2), 477-481 doi:10.1016/j.gene.2012.10.02.
@article{article, year = {2013}, pages = {477-481}, DOI = {10.1016/j.gene.2012.10.02}, keywords = {diabetes, Interleukin, age at onset, glycated hemoglobin}, journal = {Gene}, doi = {10.1016/j.gene.2012.10.02}, volume = {512}, number = {2}, issn = {0378-1119}, title = {Polymorphisms in the IL-18 and IL-12B genes and their association with the clinical outcome in Croatian patients with Type 1 diabetes}, keyword = {diabetes, Interleukin, age at onset, glycated hemoglobin} }
@article{article, year = {2013}, pages = {477-481}, DOI = {10.1016/j.gene.2012.10.02}, keywords = {diabetes, Interleukin, age at onset, gGlycated hemoglobin}, journal = {Gene}, doi = {10.1016/j.gene.2012.10.02}, volume = {512}, number = {2}, issn = {0378-1119}, title = {Polymorphisms in the IL-18 and IL-12B genes and their association with the clinical outcome in Croatian patients with Type 1 diabetes}, keyword = {diabetes, Interleukin, age at onset, gGlycated hemoglobin} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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