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Pregled bibliografske jedinice broj: 608470

Finding missing heritability in less significant loci and allelic heterogeneity: genetic variation in human height


Zhang, Ge; Karns, Rebekah; Sun, Guangyun; Indugula, Subba Rao; Cheng, Hong; Havas-Augustin, Dubravka; Novokmet, Natalija; Duraković, Zijad; Missoni, Sasa; Chakraborty, Ranajit et al.
Finding missing heritability in less significant loci and allelic heterogeneity: genetic variation in human height // PLoS One, 7 (2012), 12; 1-7 doi:10.1371/journal.pone.0047867 (međunarodna recenzija, članak, znanstveni)


Naslov
Finding missing heritability in less significant loci and allelic heterogeneity: genetic variation in human height

Autori
Zhang, Ge ; Karns, Rebekah ; Sun, Guangyun ; Indugula, Subba Rao ; Cheng, Hong ; Havas-Augustin, Dubravka ; Novokmet, Natalija ; Duraković, Zijad ; Missoni, Sasa ; Chakraborty, Ranajit ; Rudan, Pavao ; Deka, Ranjan

Izvornik
PLoS One (1932-6203) 7 (2012), 12; 1-7

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Heritability; allelic heterogeneity; human height

Sažetak
In a sample of 1 304 individuals collected from an island population of the Adriatic coast of Croatia, we assessed the extent of height variance explained by incorporating the effects of less significant height loci and multiple effective SNPs at the same loci. Approximately half of the 118 loci that achieved stringent genome-wide significance showed evidence of allelic heterogeneity. Additionally, including less significant loci and accounting for effects of allelic heterogeneity substantially improved the variance explained in height.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Etnologija i antropologija



POVEZANOST RADA


Projekt / tema
196-0342282-0291 - Promjene funkcija organa starenjem, radna sposobnost i biološka dob (Miran Čoklo, )
196-1962766-2751 - Populacijska struktura Hrvatske - antropogenetički pristup (Pavao Rudan, )

Ustanove
Institut za antropologiju

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE


Citati