engleski

Finding missing heritability in less significant loci and allelic heterogeneity: genetic variation in human height

In a sample of 1 304 individuals collected from an island population of the Adriatic coast of Croatia, we assessed the extent of height variance explained by incorporating the effects of less significant height loci and multiple effective SNPs at the same loci. Approximately half of the 118 loci that achieved stringent genome-wide significance showed evidence of allelic heterogeneity. Additionally, including less significant loci and accounting for effects of allelic heterogeneity substantially improved the variance explained in height.

heritability; allelic heterogeneity; human height

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