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Structure and mechanism of a canonical poly(ADP-ribose) glycohydrolase


Dunstan, Mark S.; Barkauskaite, Eva; Lafite, Pierre; Knežević, Claire E.; Brassington, Amy; Ahel, Marijan; Hergenrother, Paul J.; Leys, David; Ahel, Ivan
Structure and mechanism of a canonical poly(ADP-ribose) glycohydrolase // Nature Communications, 3 (2012), 6. doi:10.1038/ncomms1889 (međunarodna recenzija, članak, znanstveni)


Naslov
Structure and mechanism of a canonical poly(ADP-ribose) glycohydrolase

Autori
Dunstan, Mark S. ; Barkauskaite, Eva ; Lafite, Pierre ; Knežević, Claire E. ; Brassington, Amy ; Ahel, Marijan ; Hergenrother, Paul J. ; Leys, David ; Ahel, Ivan

Izvornik
Nature Communications (2041-1723) 3 (2012), 6;

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Identification; chromatin; inhibition; activation; proteins; model; field; PARG

Sažetak
Poly(ADP-ribosyl)ation is a reversible post-translational protein modification involved in the regulation of a number of cellular processes including DNA repair, chromatin structure, mitosis, transcription, checkpoint activation, apoptosis and asexual development. The reversion of poly(ADP-ribosyl)ation is catalysed by poly(ADP-ribose) (PAR) glycohydrolase (PARG), which specifically targets the unique PAR (1 ''-2') ribose-ribose bonds. Here we report the structure and mechanism of the first canonical PARG from the protozoan Tetrahymena thermophila. In addition, we reveal the structure of T. thermophila PARG in a complex with a novel rhodanine-containing mammalian PARG inhibitor RBPI-3. Our data demonstrate that the protozoan PARG represents a good model for human PARG and is therefore likely to prove useful in guiding structure-based discovery of new classes of PARG inhibitors.

Izvorni jezik
Engleski

Znanstvena područja
Geologija



POVEZANOST RADA


Projekt / tema
098-0982934-2712 - Organski spojevi kao molekulski obilježivači antropogenog utjecaja na okoliš (Marijan Ahel, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Autor s matičnim brojem:
Marijan Ahel, (145)
Ivan Ahel, (235841)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati