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A Simplified 3D Model of Whole Heart Electrical Activity and 12-Lead ECG Generation (CROSBI ID 188379)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Sovilj, Siniša ; Magjarević, Ratko ; H. Lovell, Nigel ; Dokos, Socrates A Simplified 3D Model of Whole Heart Electrical Activity and 12-Lead ECG Generation // Computational and mathematical methods in medicine, 2013 (2013), 134208-1-134208-10. doi: 10.1155/2013/134208

Podaci o odgovornosti

Sovilj, Siniša ; Magjarević, Ratko ; H. Lovell, Nigel ; Dokos, Socrates

engleski

A Simplified 3D Model of Whole Heart Electrical Activity and 12-Lead ECG Generation

We present a computationally-efficient three dimensional bidomain model of torso-embedded whole-heart electrical activity, with spontaneous initiation of activation in the sinoatrial node, incorporating a specialized conduction system with heterogeneous action potential morphologies throughout the heart. The simplified geometry incorporates the whole- heart as a volume source, with heart cavities, lungs and torso as passive volume conductors. We placed four surface electrodes at the limbs of the torso: V_R (right arm), V_L (left arm), V_F (left leg) and V_GND (right leg or ground) and six electrodes on the chest (V_1, V_2, V_3, V_4, V_5, V_6) to simulate the Einthoven, Goldberger- augmented and precordial leads of a standard 12- lead system. By placing an additional seven electrodes at the appropriate torso positions, we were also able to calculate the vectorcardiogram of the Frank lead system. The model was able to simulate realistic electrocardiogram (ECG) morphologies for the 12 standard leads, orthogonal X, Y and Z leads, as well as the vectorcardiogram under normal and pathological heart states. Thus simplified and easy replicable 3D cardiac bidomain model offers a compromise between computational load and model complexity and can be used as an investigative tool to adjust cell, tissue and whole-heart properties, such as setting ischemic lesions or regions of myocardial infarction, to readily investigate their effects on whole ECG morphology.

bidomain model; heart; electrical activity; volume conductor; electrocardiogram; Fitzhugh-Nagumo; action potential

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Podaci o izdanju

2013

2013.

134208-1-134208-10

objavljeno

1748-670X

10.1155/2013/134208

Povezanost rada

Elektrotehnika, Temeljne medicinske znanosti, Kliničke medicinske znanosti

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