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Pregled bibliografske jedinice broj: 607621

Central action of peripherally applied botulinum toxin type A on pain and dural protein extravasation in rat model of trigeminal neuropathy


Filipović, Boris; Matak, Ivica; Bach-Rojecky, Lidija; Lacković, Zdravko
Central action of peripherally applied botulinum toxin type A on pain and dural protein extravasation in rat model of trigeminal neuropathy // PLoS One, 7 (2012), 1. doi:10.1371/journal.pone.0029803 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 607621 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Central action of peripherally applied botulinum toxin type A on pain and dural protein extravasation in rat model of trigeminal neuropathy

Autori
Filipović, Boris ; Matak, Ivica ; Bach-Rojecky, Lidija ; Lacković, Zdravko

Izvornik
PLoS One (1932-6203) 7 (2012), 1;

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
botulinum toxin; dural neurogenic inflammation; trigeminal neuropathy; axonal transport

Sažetak
Background Infraorbital nerve constriction (IoNC) is an experimental model of trigeminal neuropathy. We investigated if IoNC is accompanied by dural extravasation and if botulinum toxin type A (BoNT/A) can reduce pain and dural extravasation in this model. Methodology/Principal Findings Rats which developed mechanical allodynia 14 days after the IoNC were injected with BoNT/A (3.5 U/kg) into vibrissal pad. Allodynia was tested by von Frey filaments and dural extravasation was measured as colorimetric absorbance of Evans blue - plasma protein complexes. Presence of dural extravasation was also examined in orofacial formalin-induced pain. Unilateral IoNC, as well as formalin injection, produced bilateral dural extravasation. Single unilateral BoNT/A injection bilaterally reduced IoNC induced dural extravasation, as well as allodynia (lasting more than 2 weeks). Similarly, BoNT/A reduced formalin- induced pain and dural extravasation. Effects of BoNT/A on pain and dural extravasation in IoNC model were dependent on axonal transport through sensory neurons, as evidenced by colchicine injections (5 mM, 2 µl) into the trigeminal ganglion completely preventing BoNT/A effects. Conclusions/Significance Two different types of pain, IoNC and formalin, are accompanied by dural extravasation. The lasting effect of a unilateral injection of BoNT/A in experimental animals suggests that BoNT/A might have a long-term beneficial effect in craniofacial pain associated with dural neurogenic inflammation. Bilateral effects of BoNT/A and dependence on retrograde axonal transport suggest a central site of its action

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
108-1080003-0001 - NEUROTRANSMITORI I NOVI MEHANIZMI DJELOVANJA LIJEKOVA I OTROVA (Lackovic, Zdravko, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Filipović, Boris; Matak, Ivica; Bach-Rojecky, Lidija; Lacković, Zdravko
Central action of peripherally applied botulinum toxin type A on pain and dural protein extravasation in rat model of trigeminal neuropathy // PLoS One, 7 (2012), 1. doi:10.1371/journal.pone.0029803 (međunarodna recenzija, članak, znanstveni)
Filipović, B., Matak, I., Bach-Rojecky, L. & Lacković, Z. (2012) Central action of peripherally applied botulinum toxin type A on pain and dural protein extravasation in rat model of trigeminal neuropathy. PLoS One, 7 (1) doi:10.1371/journal.pone.0029803.
@article{article, year = {2012}, DOI = {10.1371/journal.pone.0029803}, keywords = {botulinum toxin, dural neurogenic inflammation, trigeminal neuropathy, axonal transport}, journal = {PLoS One}, doi = {10.1371/journal.pone.0029803}, volume = {7}, number = {1}, issn = {1932-6203}, title = {Central action of peripherally applied botulinum toxin type A on pain and dural protein extravasation in rat model of trigeminal neuropathy}, keyword = {botulinum toxin, dural neurogenic inflammation, trigeminal neuropathy, axonal transport} }
@article{article, year = {2012}, DOI = {10.1371/journal.pone.0029803}, keywords = {botulinum toxin, dural neurogenic inflammation, trigeminal neuropathy, axonal transport}, journal = {PLoS One}, doi = {10.1371/journal.pone.0029803}, volume = {7}, number = {1}, issn = {1932-6203}, title = {Central action of peripherally applied botulinum toxin type A on pain and dural protein extravasation in rat model of trigeminal neuropathy}, keyword = {botulinum toxin, dural neurogenic inflammation, trigeminal neuropathy, axonal transport} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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