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Surface-enhanced Raman scattering study of the binding modes of a dibenzotetraaza[14]annulene derivative with DNA/RNA polynucleotides


Miljanić, Snežana; Dijanošić, Adriana; Kalac, Matea; Radić Stojković, Marijana; Piantanida, Ivo; Pawlica, Dariusz; Eilmes, Julita
Surface-enhanced Raman scattering study of the binding modes of a dibenzotetraaza[14]annulene derivative with DNA/RNA polynucleotides // Croatica chemica acta, 85 (2012), 4; 577-584 doi:10.5562/cca2106 (međunarodna recenzija, članak, znanstveni)


Naslov
Surface-enhanced Raman scattering study of the binding modes of a dibenzotetraaza[14]annulene derivative with DNA/RNA polynucleotides

Autori
Miljanić, Snežana ; Dijanošić, Adriana ; Kalac, Matea ; Radić Stojković, Marijana ; Piantanida, Ivo ; Pawlica, Dariusz ; Eilmes, Julita

Izvornik
Croatica chemica acta (0011-1643) 85 (2012), 4; 577-584

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Surface-enhanced Raman scattering; binding; polynucleotide; annulene

Sažetak
Binding modes of a dibenzotetraaza[14]annulene (DBTAA) derivative with synthetic nucleic acids were studied using surface-enhanced Raman spectroscopy (SERS). Changes in SERS intensity and appearance of new bands in spectra were attributed to different complexes formed between the DBTAA molecules and DNA/RNA polynucleotides. A decrease in intensity pointed to intercalation as the dominant binding mode of the annulene derivative with poly dGdC-poly dGdC and poly rA-poly rU, whereas new bands in the spectra at 735 cm–1 and 1345 cm–1 revealed binding within the minor groove of poly dAdT-poly dAdT. When all the dominant binding sites were occupied, SERS spectra implied that small molecules bind on the outside of the DNA analogues, while exist mainly as free molecules in equimolar ratio with the synthetic RNA polynucleotide, thereby indicating higher affinity for DNA than for RNA.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Ivo Piantanida, )
119-1191342-2959 - Spektroskopska analiza nezasićenih sustava i spojeva metala (Snežana Miljanić, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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