engleski

Viruses as self-assembled nanoparticles

I will present a physical approach to assembly [1, 5, 7, 9], structure [2, 3, 5, 8], and elastic response [6, 10] of viruses. The interactions guiding the complexation of viral proteins with its RNA molecule [7, 9], but also generic polyelectrolytes and functionalized golden nanoparticles [4], will be elucidated. A possible „evolutionary design“ of proteins enabling a reliable self-assembly in in vivo and in vitro conditions will be discussed [11]. [1] A. Šiber, A. Lošdorfer Božič, and R. Podgornik "Energies and pressures in viruses: contribution of nonspecific electrostatic interactions“, Phys.Chem.Chem.Phys. 14, 3746 (2012). [2] A. Leforestier, A. Šiber, F. Livolant, and R. Podgornik "Protein-DNA Interactions Determine the Shapes of DNA Toroids Condensed in Virus Capsids“, Biophys. J. 100, 2209 (2011). [3] A. Lošdorfer Božič, A. Šiber, and R. Podgornik "Electrostatic self-energy of a partially formed spherical shell in salt solution: Application to stability of tethered and fluid shells as models for viruses and vesicles“, Phys. Rev. E 83, 041916 (2011). [4] A. Šiber, R. Zandi and R. Podgornik "Thermodynamics of nanospheres encapsulated in virus capsids“, Phys. Rev. E 81, 051919 (2010). [5] A. Šiber and A. Majdandžić, "Spontaneous curvature as a regulator of the size of virus capsids“, Phys. Rev. E 80, 021910 (2009). [6] A. Šiber and R. Podgornik, "Stability of elastic icosadeltahedral shells under uniform external pressure: Application to viruses under osmotic pressure“, Phys. Rev. E 79, 011919 (2009). [7] A. Šiber and R. Podgornik, "Nonspecific interactions in spontaneous assembly of empty versus functional single-stranded RNA viruses“, Phys. Rev. E 78, 051915 (2008). [8] A. Šiber, M. Dragar, V.A. Parsegian, and R. Podgornik, "Packing nanomechanics of viral genomes“, Eur. Phys. J. E 26, 317 (2008). [9] A. Šiber and R. Podgornik, "Role of electrostatic interactions in the assembly of empty spherical viral capsids", Phys. Rev. E 76, 061906 (2007). [10] A. Šiber, "Buckling transition in icosahedral shells subjected to volume conservation constraint and pressure: Relations to virus maturation", Phys. Rev. E 73, 061915 (2006). [11] A. Lošdorfer Božič, A. Šiber, and R. Podgornik, „How simple can a model of an empty viral capsid be? Charge distributions in viral capsids“, Journal of Biological Physics, in press

virus; nanoparticle; assembly

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