The effect of pentadecapeptide BPC 157 on malondialdehyde levels in brain and fine motorics impairment in rat model of haloperidol and methamphetamine induced neurotoxicity (CROSBI ID 592786)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Šuran, Jelena ; Prišć, Martina ; Beluškov, Ivan ; Sikirić, Predrag ; Božić, Frane ; Sakar, Darko
engleski
The effect of pentadecapeptide BPC 157 on malondialdehyde levels in brain and fine motorics impairment in rat model of haloperidol and methamphetamine induced neurotoxicity
Stabile gastric pentadecapeptide BPC 157, Gly–Glu– Pro–Pro–Pro–Gly–Lys–Pro–Ala–Asp–Asp–Ala–Gly–Leu– Val, MW 1419, has a variety of protective effects in different organs, as well as nervous system. It antagonizes haloperidol-induced behavioural supersensitivity to amphetamine which, results in dopaminergic neurotoxicity and nigrostriatum damage due to increased lipid peroxidation. Currently, BPC 157 neuroprotective effects are evaluted in a model of haloperidol- and methamphetamine-induced neurotoxicity. These models result in impaired motoric function and increased lipid peroxidation in different brain regions. The purpose of this research was to asses BPC 157 protective effects on nigrostriatum in rat model of haloperidol and methamphetamine induced neurotoxicity using fine motoric in rats as indicator of nigrostriatum function and malondialdehyde (MDA) levels as lipid peroxidation marker.
BPC 157; methamphetamine; malondialdehyde
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Podaci o prilogu
156-157.
2012.
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objavljeno
Podaci o matičnoj publikaciji
Journal of Veterinary Pharmacology and Therapeutics
Riviere, Jim E. ; Fink-Gremmels, J.
Wiley-Blackwell
1365-2885
Podaci o skupu
12th International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT 2012)
poster
08.07.2012-12.07.2012
Noordwijkerhout, Nizozemska
Povezanost rada
Temeljne medicinske znanosti