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The effect of pentadecapeptide BPC 157 on malondialdehyde levels in brain and fine motorics impairment in rat model of haloperidol and methamphetamine induced neurotoxicity (CROSBI ID 592786)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Šuran, Jelena ; Prišć, Martina ; Beluškov, Ivan ; Sikirić, Predrag ; Božić, Frane ; Sakar, Darko The effect of pentadecapeptide BPC 157 on malondialdehyde levels in brain and fine motorics impairment in rat model of haloperidol and methamphetamine induced neurotoxicity // Journal of Veterinary Pharmacology and Therapeutics / Riviere, Jim E. ; Fink-Gremmels, J. (ur.). 2012. str. 156-157

Podaci o odgovornosti

Šuran, Jelena ; Prišć, Martina ; Beluškov, Ivan ; Sikirić, Predrag ; Božić, Frane ; Sakar, Darko

engleski

The effect of pentadecapeptide BPC 157 on malondialdehyde levels in brain and fine motorics impairment in rat model of haloperidol and methamphetamine induced neurotoxicity

Stabile gastric pentadecapeptide BPC 157, Gly–Glu– Pro–Pro–Pro–Gly–Lys–Pro–Ala–Asp–Asp–Ala–Gly–Leu– Val, MW 1419, has a variety of protective effects in different organs, as well as nervous system. It antagonizes haloperidol-induced behavioural supersensitivity to amphetamine which, results in dopaminergic neurotoxicity and nigrostriatum damage due to increased lipid peroxidation. Currently, BPC 157 neuroprotective effects are evaluted in a model of haloperidol- and methamphetamine-induced neurotoxicity. These models result in impaired motoric function and increased lipid peroxidation in different brain regions. The purpose of this research was to asses BPC 157 protective effects on nigrostriatum in rat model of haloperidol and methamphetamine induced neurotoxicity using fine motoric in rats as indicator of nigrostriatum function and malondialdehyde (MDA) levels as lipid peroxidation marker.

BPC 157; methamphetamine; malondialdehyde

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Podaci o prilogu

156-157.

2012.

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objavljeno

Podaci o matičnoj publikaciji

Journal of Veterinary Pharmacology and Therapeutics

Riviere, Jim E. ; Fink-Gremmels, J.

Wiley-Blackwell

1365-2885

Podaci o skupu

12th International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT 2012)

poster

08.07.2012-12.07.2012

Noordwijkerhout, Nizozemska

Povezanost rada

Temeljne medicinske znanosti

Indeksiranost