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Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157


Sikirić, Predrag; Seiwerth, Sven; Ručman, Rudolf; Turković, Branko; Stančić-Rokotov, Dinko; Brčić, Luka; Sever, Marko; Kliček, Robert; Radić, Božo; Drmić, Domagoj et al.
Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157 // Current pharmaceutical design, 19 (2013), 1; 76-83 doi:10.2174/1381612811306010076 (međunarodna recenzija, pregledni rad, znanstveni)


Naslov
Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157

Autori
Sikirić, Predrag ; Seiwerth, Sven ; Ručman, Rudolf ; Turković, Branko ; Stančić-Rokotov, Dinko ; Brčić, Luka ; Sever, Marko ; Kliček, Robert ; Radić, Božo ; Drmić, Domagoj ; Ilić, Spomenko ; Kolenc, Danijela ; Aralica, Gorana ; Safić, Hana ; Šuran, Jelena ; , Rak, Davor ; Džidić, Senka ; Vrčić, Hrvoje ; Sebečić, Božidar

Izvornik
Current pharmaceutical design (1381-6128) 19 (2013), 1; 76-83

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
BPC 157 ; NSAID

Sažetak
Stable gastric pentadecapeptide BPC 157 is an anti-ulcer peptidergic agent, proven in clinical trials to be both safe in inflammatory bowel disease (PL-10, PLD-116, PL 14736) and wound healing, stable in human gastric juice, with no toxicity being reported. Recently, we claim that BPC 157 may be used as an antidote against NSAIDs. We focused on BPC 157 beneficial effects on stomach, duodenum, intestine, liver and brain injuries, adjuvant arthritis, pain, hyper/hypothermia, obstructive thrombus formation and thrombolysis, blood vessel function, counteraction of prolonged bleeding and thrombocytopenia after application of various anticoagulants and anti-platelet agents and wound healing improvement. The arguments for BPC 157 antidote activity (i.e., the role of BPC 157 in cytoprotection, being a novel mediator of Roberts cytoprotection and BPC 157 beneficial effects on NSAID mediated lesions in the gastrointestinal tract, liver and brain and finally, counteraction of aspirin-induced prolonged bleeding and thrombocytopenia) obviously have a counteracting effect on several established side-effects of NSAID use. The mentioned variety of the beneficial effects portrayed by BPC 157 may well be a foundation for establishing BPC 157 as a NSAID antidote since no other single agent has portrayed a similar array of effects. Unlike NSAIDs, a very high safety (no reported toxicity (LD1 could be not achieved)) profile is reported for BPC 157. Also, unlike the different dosage levels of aspirin, as a NSAID prototype, which differ by a factor of about ten, all these beneficial and counteracting effects of BPC 157 were obtained using the equipotent dosage (µg, ng/kg) in parenteral or peroral regimens.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1080321-0389 - Utjecaj pentadekapeptida BPC 157 na ženski urogenitalni sustav (Hrvoje Vrčić, )
108-1083570-3611 - Pentadekapeptid BPC 157- učinkovita terapija ozljeda mišića i tetive (Božidar Šebečić, )
108-1083570-3634 - Genetička istraživanja učinka BPC-157 na mikroorganizmima (Senka Džidić, )
108-1083570-3635 - Pentadekapeptid BPC 157 - daljnja istraživanja (Predrag Sikirić, )
108-1083570-3643 - Kvantitativna analiza i prijenos slike u patologiji (Sven Seiwerth, )

Ustanove
Veterinarski fakultet, Zagreb,
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • BIOSIS Previews (Biological Abstracts)
  • Medical and Pharmaceutical Biotechnology Abstracts
  • MEDLINE
  • Biochemistry & Biophysics Citation Index


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