engleski

1-Heteroaryl-6-(3, 4-dichlorophenyl)-3-azabicyclo[4.1.0]heptane : Further insights into a class of triple re-uptake inhibitors

Further exploration around the recently disclosed potent triple re-uptake inhibitor 6-(3, 4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane led to the identification of a new series of potent triple re-uptake inhibitors endowed with good developability characteristics. The insertion of a further aryl moiety into the template allowed the ‘titration’ of the SERT/NET/DAT ratio leading to the identification of further tools in this important area.

triple re-uptake inhibitors; pharmacophore; SERT; NET; DAT

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