Single Nucleotide Polymorphism in the Interleukin 12B Gene is Associated With Risk for Breast Cancer Development (CROSBI ID 188219)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Kaarvatn, Marikken H. ; Vrbanec, Jurica ; Kulić, Ana ; Knežević, Jelena ; Petričević, Branka ; Balen, Sanja ; Vrbanec, Damir ; Dembić, Zlatko
engleski
Single Nucleotide Polymorphism in the Interleukin 12B Gene is Associated With Risk for Breast Cancer Development
We analysed the association of a single nucleotide polymorphism (SNP) in the gene encoding the IL-12 subunit p40 (IL12B, rs3212227, A>C) with breast cancer. The SNPs allelic and genotypic frequencies were compared between patients (n = 191) and healthy (n = 194) women in a case-control study from Croatia. The major allele (A) was associated with susceptibility to breast cancer (P = 0.003 ; OR = 1.67 ; 95% CI: 1.17-2.38). Likewise, the minor allele (C) was significantly correlated with protection (P = 0.003 ; OR = 0.60 ; 95% CI: 0.42-0.86). At the genotype level, AA homozygosity was significantly associated with predisposition to disease (P = 0.013 ; OR = 1.68, 95% CI: 1.09-2.59), whereas the minor allele homozygosity (CC) was correlated with protection to disease (P = 0.020, OR = 0.28, 95% CI: 0.09-0.91). The heterozygous genotype showed no significant correlation with disease. The product of the IL12B gene (IL-12 p40) can either form a homodimeric cytokine or be part of two pro-inflammatory (IL-12 and IL-23) cytokines. It is presently unclear whether the major allele is associated with higher or lower protein levels of IL-12 p40 and IL-12 p70, which are critical in inflammation and adaptive immune responses. However, as the A allele is high producer of IL12B (p40) mRNA, these results might imply that higher levels of IL-12 p40 (either as homodimers or joined with one or both of the other two subunits) predispose to breast cancer.
IL12B; breast cancer; SNP; genotype
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Podaci o izdanju
76 (3)
2012.
329-335
objavljeno
0300-9475
10.1111/j.1365-3083.2012.02736.x
Povezanost rada
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita