engleski

Pathogenesis of Tularemia

Francisella tularensis is a highly infectious intracellular bacterium that causes disease tularemia, which can be transmitted between mammals by arthropod vectors. Entry of F. tularensis into macrophages is mediated by looping phagocytosis and is associated with signalling through Syk tyrosine kinase. Within macrophages and arthropod-derived cells, the Francisella-containing phagosome matures transiently into an acidified late endosome-like phagosome with limited fusion to lysosomes followed by rapid bacterial escape into the cytosol within 30-60 min, and bacterial proliferation within the cytosol. The Francisella pathogenicity island, which potentially encodes a putative type VI secretion system, is essential for phagosome biogenesis and bacterial escape into the cytosol within macrophages cells.

Francisella; pathogenesis; life cycle

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