engleski

Proteomic profiling of intestinal proteins in TFF2 mice

Trefoil factor family (TFFs) comprises three small proteins (TFF1, TFF2 and TFF3) predominantly found in mucous epithelia of gastric system but they also found in epithelia of different organs like respiratory tract, uterus, conjunctiva, thyroid gland etc. TFFs play multifunctional role in protection of mucosa through participation in apoptosis, cell migration and immune response. Expression of Tffs is deregulated in different tumors. Biological effect of proteins is best evaluated in mouse knock out models that are deficient in a specific protein. To assess the role of Tff2 protein in intestine we have compared global protein status of Tff2 knock-out mice versus wild type mice by means of two-dimensional gel electrophoresis.

TFF2; 2-DE; proteomics

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