Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi !

Possible role of cellular senescence in the pathogenesis of psoriasis – expression of 53BP1, γH2AX, p16, p21 and p53 in lesional psoriatic skin (CROSBI ID 592182)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Manestar Blažić, Teo ; Peternel, Sandra ; Kaštelan, Marija ; Brajac, Ines Possible role of cellular senescence in the pathogenesis of psoriasis – expression of 53BP1, γH2AX, p16, p21 and p53 in lesional psoriatic skin // 6th Croatian - Italian Symposium on Psoriasis, Abstract Book. Rijeka, 2012

Podaci o odgovornosti

Manestar Blažić, Teo ; Peternel, Sandra ; Kaštelan, Marija ; Brajac, Ines

engleski

Possible role of cellular senescence in the pathogenesis of psoriasis – expression of 53BP1, γH2AX, p16, p21 and p53 in lesional psoriatic skin

Introduction & Objectives: Cellular senescence is a state of permanent cell cycle arrest in the G0 phase. Its importance during carcinogenesis is already recognized, while its role in other pathologies is intensively studied. Recent studies have shown that the process of cellular senescence implies increased secretion of pro-inflammatory proteins and that might be important to chronic inflammation. Entry into senescence is regulated by at least two signalling pathways, the p16/Rb-dependent pathway and the DNA damage response (DDR) pathway. The objective of this study was to analyse the expression of markers of DDR and cellular senescence in psoriatic lesions and discuss the possible role of cellular senescence in the pathogenesis of psoriasis. Material & Methods: The study comprised 10 tissue samples of psoriatic lesions and 10 of healthy skin. Immunohistochemical and immunofluorescent staining was performed on 3μm formalin-fixed paraffin-embedded sections. The percentage of keratinocytes positive for 53BP1 foci, γH2AX, nuclear p16, p21 and p53 were determined. The unpaired t-test was used to compare the two groups. Differences with p<0.05 were considered statistically significant. Results: The number of cells positive for 53BP1foci, γH2AX, p16, p21 and p53 was significantly higher in psoriasis when compared to normal skin (p<0.05). Conclusion: The increased presence of DDR and cellular senescence markers in psoriasis could be related to the high cellular proliferation, which is one the hallmarks of psoriatic epidermis. The presence of senescent cells could be one of the mechanisms that cause and maintain chronic inflammation process in the psoriatic plaque. Further studies are needed to understand this connection.

psoriasis; DNA damage response; cellular senescence

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

2012.

objavljeno

Podaci o matičnoj publikaciji

6th Croatian - Italian Symposium on Psoriasis, Abstract Book

Rijeka:

Podaci o skupu

6th Croatian- Italian symposium on psoriasis

predavanje

16.11.2012-17.11.2012

Rijeka, Hrvatska

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti