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izvor podataka: crosbi

Osteopontin expression is an independent factor for poor survival in oral squamous cell carcinoma: a computer assisted analysis on TMA sections (CROSBI ID 187839)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Avirović, Manuela ; Matušan-Ilijaš, Koviljka ; Damante, Giuseppe ; Fabrro, Dora ; Cerović, Robert ; Juretić, Mirna ; Grahovac, Blaženka ; Jonjić, Nives ; Lučin, Ksenija Osteopontin expression is an independent factor for poor survival in oral squamous cell carcinoma: a computer assisted analysis on TMA sections // Journal of oral pathology & medicine, 42 (2012), 8; 620-626. doi: 10.1111/jop.12055

Podaci o odgovornosti

Avirović, Manuela ; Matušan-Ilijaš, Koviljka ; Damante, Giuseppe ; Fabrro, Dora ; Cerović, Robert ; Juretić, Mirna ; Grahovac, Blaženka ; Jonjić, Nives ; Lučin, Ksenija

engleski

Osteopontin expression is an independent factor for poor survival in oral squamous cell carcinoma: a computer assisted analysis on TMA sections

Ostepontin (OPN) is noncollagenous extracellular matrix protein involved in various physiological and pathological events, including tumor progression. The aim of this study was to analyze the expression of OPN in normal oral mucosa and oral squamous cell carcinoma (OSCC), and to assess its prognostic significance. The expression of OPN was immunohistochemicaly analyzed in 86 OSCC and compared to clinicopathological variable such as tumor size, nodal stage, WHO clinical stage, Ki-67 proliferation index, and patients' outcome. OPN mRNA was analyzed using quantitative real-time PCR and compared with protein OPN expression and clinical outcome in 18 OSCC samples. The expression of OPN protein was found in OSCC tumor cells (t-OPN) and various stromal cells (s-OPN). High level of t-OPN expression was associated with nodal stage (p=0, 045), WHO clinical stage (p=0, 033), and poor clinical outcome (p=0.022). In multivariate analysis OPN emerged as the independent factor for survival (p=0.049). Although correlated with t-OPN expression (p=0, 005), s-OPN expression showed only a trend for a longer survival (p=0.161). OPN is upregulated in tumor and stromal OSCC cells. Tumor cell-derived OPN is involved in tumor progression and can independently predict the clinical outcome. Stromal-derived OPN probably has different function compared to OPN secreted from tumor cells.

cancer; oral; osteopontin; Tissue Array Analysis

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Podaci o izdanju

42 (8)

2012.

620-626

objavljeno

0904-2512

10.1111/jop.12055

Povezanost rada

Kliničke medicinske znanosti

Poveznice
Indeksiranost