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Pregled bibliografske jedinice broj: 604113

JAK2-V617F mutation is associated with clinical and laboratory features of myeloproliferative neoplasms


Naćinović Duletić, Antica; Dekanić, Andrea; Hadžisejdić, Ita; Kušen, Ivona; Matušan-Ilijaš, Koviljka; Grohovac, Dragana; Grahovac, Blaženka; Jonjić, Nives
JAK2-V617F mutation is associated with clinical and laboratory features of myeloproliferative neoplasms // Collegium antropologicum, 36 (2012), 3; 859-865 (međunarodna recenzija, članak, znanstveni)


Naslov
JAK2-V617F mutation is associated with clinical and laboratory features of myeloproliferative neoplasms

Autori
Naćinović Duletić, Antica ; Dekanić, Andrea ; Hadžisejdić, Ita ; Kušen, Ivona ; Matušan-Ilijaš, Koviljka ; Grohovac, Dragana ; Grahovac, Blaženka ; Jonjić, Nives

Izvornik
Collegium antropologicum (0350-6134) 36 (2012), 3; 859-865

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
JAK2-V617F; essential thrombocythemia; polycythemia vera; primary myelofibrosis
(JAK2-V617F; essential thrombocythemia; polycythemia vera; primary myelofibrosis.)

Sažetak
The aim of this study is to investigate the differences of clinical and laboratory parameters between patients with JAK2-V617F positive myeloproliferative neoplasms (MPNs) and JAK2 wild type MPNs. DNA was isolated from peripheral blood granulocytes of 106 patients treated at Rijeka University Hospital Center: 41 with polycythemia vera (PV), 43 with essential thrombocythemia (ET), 9 with primary myelofibrosis (PMF) and 13 with myeloproliferative neoplasm- -unclassifiable (MPN-u). The JAK2-V617F mutation was detected using allele specific PCR. Laboratory and clinical parameters were obtained from patient’s medical records. The JAK2-V617F mutation was detected in 69% (73/106) patients with MPNs. The results revealed significantly different prevalence of JAK2-V617F mutation, between MPNs entities: 88% in PV, 58% in ET, 56% in PMF and 54% in MPNs-unclassified disorders. The JAK2-V617F mutation significantly correlated with higher leukocyte count and alkaline phosphatase score in ET group and with higher platelets count, leukocyte alkaline phosphatase score and serum lactate dehydrogenase in PV group. Vascular events were associated with elevated platelets count in wholeMPNs group, with higher platelets and leukocyte count in ET and with splenomegaly in PV patients. Clinical and laboratory data revealed significant contribution of JAK2-V617F mutation to the development of clinical phenotype in patients with distinct subgroups of MPNs.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0620095-0082 - REGULACIJSKI ČIMBENICI ANGIOGENEZE U PROGNOZI TUMORA (Nives Jonjić, )
062-1081872-0091 - Angiogeneza u agresivnih ne-Hodgkinovih limfoma (Antica Duletić-Načinović, )

Ustanove
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE