Napredna pretraga

Pregled bibliografske jedinice broj: 603584

Synthesis, DNA Interactions and Anticancer Evaluation of Novel Diamidine Derivatives of 3, 4-Ethylenedioxythiophene


Stolić, Ivana; Avdičević, Monika; Bregović, Nikola; Piantanida, Ivo; Glavaš-Obrovac, Ljubica; Bajić, Miroslav
Synthesis, DNA Interactions and Anticancer Evaluation of Novel Diamidine Derivatives of 3, 4-Ethylenedioxythiophene // Croatica chemica acta, 85 (2012), 4; 457-467 doi:10.5562/cca2141 (međunarodna recenzija, članak, znanstveni)


Naslov
Synthesis, DNA Interactions and Anticancer Evaluation of Novel Diamidine Derivatives of 3, 4-Ethylenedioxythiophene

Autori
Stolić, Ivana ; Avdičević, Monika ; Bregović, Nikola ; Piantanida, Ivo ; Glavaš-Obrovac, Ljubica ; Bajić, Miroslav

Izvornik
Croatica chemica acta (0011-1643) 85 (2012), 4; 457-467

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Amide-amidines; 3; 4-ethylenedioxythiophene; diarylamidine; DNA/RNA binding; antitumor activity

Sažetak
Eight novel diamidino 3, 4-ethylenedioxythiophene-2, 5-dicarboxanilides (5a–h), obtained by condensation reaction of 3, 4-ethylenedioxythiophene-2, 5-dicarbonyl chloride and corresponding 3- or 4-aminobenzamidines, were evaluated for interactions with double-stranded DNA and RNA, and their cytotoxicity was assayed against the panel of human cancer cell lines. All compounds preferentially bind into the minor groove of DNA and had higher affinity for DNA than for RNA. Compounds 5a–h showed a moderate antiproliferative effect toward the panel of seven carcinoma cells line, whereby the highest inhibitory potential was displayed by compound 5a with unsubstituted amidino moieties in para position.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
053-0982914-2965 - Dizajn i sinteza bisamidina sa protutumorskim djelovanjem (Miroslav Bajić, )
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Ivo Piantanida, )
119-1191342-2960 - Elektroliti i koordinacijske reakcije u otopini (Vladislav Tomišić, )
219-0982914-2176 - Mehanizam bioloških učinaka novih malih molekula na stanice tumora čovjeka (Ljubica Glavaš Obrovac, )
219-0982914-2179 - Uloga malih zaštitinih TFF proteina u zdravlju i bolesti (Tatjana Belovari, )

Ustanove
Veterinarski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
Medicinski fakultet, Osijek

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Uključenost u ostale bibliografske baze podataka:


  • CA Search (Chemical Abstracts)


Citati