Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 603503

Highly attenuated MCMV vector expressing NKG2D ligand RAE-1 gamma provides long-lived memory CD8+T cells with outstanding protective capacity


Tršan, Tihana; Busche, Andreas; Babić, Marina; Tomić, Adriana; Golemac, Mijo; Lemmermann, Niels; Brinkmann, Melanie; Jäger, Wiebke; Abram, Maja; Krmpotić, Astrid et al.
Highly attenuated MCMV vector expressing NKG2D ligand RAE-1 gamma provides long-lived memory CD8+T cells with outstanding protective capacity // Congenital CMV Conference and the International CMV/Betaherpesvirus Workshop : Book of abstracts
San Francisco, SAD, 2012. (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)


Naslov
Highly attenuated MCMV vector expressing NKG2D ligand RAE-1 gamma provides long-lived memory CD8+T cells with outstanding protective capacity

Autori
Tršan, Tihana ; Busche, Andreas ; Babić, Marina ; Tomić, Adriana ; Golemac, Mijo ; Lemmermann, Niels ; Brinkmann, Melanie ; Jäger, Wiebke ; Abram, Maja ; Krmpotić, Astrid ; Messerle, Martin ; Jonjić, Stipan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Congenital CMV Conference and the International CMV/Betaherpesvirus Workshop : Book of abstracts / - , 2012

Skup
Congenital CMV Conference and the International CMV/Betaherpesvirus Workshop

Mjesto i datum
San Francisco, SAD, 29.10.-02.11.2012

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
MCMV; NKG2D ligand RAE-1; CD8+T cells

Sažetak
There is a large number of pathogens for which post-infection acquired immunity does not fully protect against re-infection and disease. Therefore, vaccines which offer superior protection compared to the one following natural infection are needed. We have previously demonstrated that a recombinant CMV expressing a cellular ligand for the NKG2D receptor has tremendous potential for the induction of a potent antiviral immune response in spite of a strong attenuation in vivo. In this study we have used a MCMV vector expressing NKG2D ligand RAE-1gamma and the CD8+ T cell epitope of Listeria monocytogenes and have demonstrated that the expression of NKG2D ligand dramatically enhanced the effectiveness and longevity of epitope-specific CD8+ T cell response, conferring protection against a subsequent challenge infection with Listeria monocytogenes. We believe that a similar approach can be used in CD8+ T cell-based vaccination strategies against multiple human pathogens.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Stipan Jonjić, )

Ustanove
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju

Tršan, Tihana; Busche, Andreas; Babić, Marina; Tomić, Adriana; Golemac, Mijo; Lemmermann, Niels; Brinkmann, Melanie; Jäger, Wiebke; Abram, Maja; Krmpotić, Astrid et al.
Highly attenuated MCMV vector expressing NKG2D ligand RAE-1 gamma provides long-lived memory CD8+T cells with outstanding protective capacity // Congenital CMV Conference and the International CMV/Betaherpesvirus Workshop : Book of abstracts
San Francisco, SAD, 2012. (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)
Tršan, T., Busche, A., Babić, M., Tomić, A., Golemac, M., Lemmermann, N., Brinkmann, M., Jäger, W., Abram, M. & Krmpotić, A. (2012) Highly attenuated MCMV vector expressing NKG2D ligand RAE-1 gamma provides long-lived memory CD8+T cells with outstanding protective capacity. U: Congenital CMV Conference and the International CMV/Betaherpesvirus Workshop : Book of abstracts.
@article{article, year = {2012}, keywords = {MCMV, NKG2D ligand RAE-1, CD8+T cells}, title = {Highly attenuated MCMV vector expressing NKG2D ligand RAE-1 gamma provides long-lived memory CD8+T cells with outstanding protective capacity}, keyword = {MCMV, NKG2D ligand RAE-1, CD8+T cells}, publisherplace = {San Francisco, SAD} }