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Pregled bibliografske jedinice broj: 602851

Microphthalmia-associated transcription factor as marker for detection of circulating melanoma cells in patients with stage I-III melanoma


Šamija, Ivan; Lukač, Josip; Marić-Brozić, Jasmina; Šitum, Mirna; Kusić, Zvonko
Microphthalmia-associated transcription factor as marker for detection of circulating melanoma cells in patients with stage I-III melanoma // Second Meeting of the Croatian Association for Cancer Research with International Participation, Final Programme and Abstract Book / Levanat, Sonja ; Levačić Cvok, Mirela ; Musani, Vesna ; Car, Diana ; Osmak, Maja ; Herak Bosnar, Maja ; Slade, Neda ; Stojanović, Nikolona (ur.).
Zagreb: Croatian Association for Cancer Research, 2012. str. 36-36 (predavanje, domaća recenzija, sažetak, znanstveni)


CROSBI ID: 602851 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Microphthalmia-associated transcription factor as marker for detection of circulating melanoma cells in patients with stage I-III melanoma

Autori
Šamija, Ivan ; Lukač, Josip ; Marić-Brozić, Jasmina ; Šitum, Mirna ; Kusić, Zvonko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Second Meeting of the Croatian Association for Cancer Research with International Participation, Final Programme and Abstract Book / Levanat, Sonja ; Levačić Cvok, Mirela ; Musani, Vesna ; Car, Diana ; Osmak, Maja ; Herak Bosnar, Maja ; Slade, Neda ; Stojanović, Nikolona - Zagreb : Croatian Association for Cancer Research, 2012, 36-36

Skup
Second Meeting of the Croatian Association for Cancer Research with International Participation

Mjesto i datum
Zagreb, Hrvatska, 08.11.2012. - 09.11.2012

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
melanoma; microphthalmia-associated transcription factor; tyrosinase; circulating cancer cells; RT-PCR

Sažetak
The aim of this study was to determine prognostic value of microphthalmia-associated transcription factor (MITF) as a marker for the detection of circulating melanoma cells in stage I-III melanoma patients and compare it to tyrosinase. Blood samples from 179 melanoma patients in AJCC stages I-III and 40 healthy volunteers were analyzed. RNA was isolated from mononuclear cell fraction of the blood and assayed by RT-PCR for the expression of MITF and tyrosinase. All samples from healthy volunteers were negative for both MITF and tyrosinase. Out of 179 samples from melanoma patients 25 were positive for MITF, 14 for tyrosinase, and 2 for both MITF and tyrosinase. Analysis of MITF as an additional marker to tyrosinase improved detection of circulating melanoma cells in comparison to tyrosinase analysis alone (37 versus 14 positive patients). Positive value of MITF was associated with shorter progression-free survival (p=0.043), while there was no significant association between the value of MITF and overall survival. Value of MITF was selected with multivariate analysis as independent prognostic factor for progression-free survival, while the only independent prognostic factor for overall survival was stage of disease. This study has shown that MITF is a specific marker for detection of circulating melanoma cells that has a prognostic value in melanoma patients. Analysis of MITF in addition to tyrosinase improved the detection of circulating melanoma cells in melanoma patients.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
134-1342428-2427 - Cirkulirajuće tumorske stanice u bolesnika sa solidnim tumorima (Kovačević, Dujo, MZOS ) ( CroRIS)
134-1342428-2430 - Karcinogeneza u štitnjači i gušavost u Hrvatskoj (Kusić, Zvonko, MZOS ) ( CroRIS)

Ustanove:
KBC "Sestre Milosrdnice"


Citiraj ovu publikaciju:

Šamija, Ivan; Lukač, Josip; Marić-Brozić, Jasmina; Šitum, Mirna; Kusić, Zvonko
Microphthalmia-associated transcription factor as marker for detection of circulating melanoma cells in patients with stage I-III melanoma // Second Meeting of the Croatian Association for Cancer Research with International Participation, Final Programme and Abstract Book / Levanat, Sonja ; Levačić Cvok, Mirela ; Musani, Vesna ; Car, Diana ; Osmak, Maja ; Herak Bosnar, Maja ; Slade, Neda ; Stojanović, Nikolona (ur.).
Zagreb: Croatian Association for Cancer Research, 2012. str. 36-36 (predavanje, domaća recenzija, sažetak, znanstveni)
Šamija, I., Lukač, J., Marić-Brozić, J., Šitum, M. & Kusić, Z. (2012) Microphthalmia-associated transcription factor as marker for detection of circulating melanoma cells in patients with stage I-III melanoma. U: Levanat, S., Levačić Cvok, M., Musani, V., Car, D., Osmak, M., Herak Bosnar, M., Slade, N. & Stojanović, N. (ur.)Second Meeting of the Croatian Association for Cancer Research with International Participation, Final Programme and Abstract Book.
@article{article, author = {\v{S}amija, Ivan and Luka\v{c}, Josip and Mari\'{c}-Brozi\'{c}, Jasmina and \v{S}itum, Mirna and Kusi\'{c}, Zvonko}, year = {2012}, pages = {36-36}, keywords = {melanoma, microphthalmia-associated transcription factor, tyrosinase, circulating cancer cells, RT-PCR}, title = {Microphthalmia-associated transcription factor as marker for detection of circulating melanoma cells in patients with stage I-III melanoma}, keyword = {melanoma, microphthalmia-associated transcription factor, tyrosinase, circulating cancer cells, RT-PCR}, publisher = {Croatian Association for Cancer Research}, publisherplace = {Zagreb, Hrvatska} }
@article{article, author = {\v{S}amija, Ivan and Luka\v{c}, Josip and Mari\'{c}-Brozi\'{c}, Jasmina and \v{S}itum, Mirna and Kusi\'{c}, Zvonko}, year = {2012}, pages = {36-36}, keywords = {melanoma, microphthalmia-associated transcription factor, tyrosinase, circulating cancer cells, RT-PCR}, title = {Microphthalmia-associated transcription factor as marker for detection of circulating melanoma cells in patients with stage I-III melanoma}, keyword = {melanoma, microphthalmia-associated transcription factor, tyrosinase, circulating cancer cells, RT-PCR}, publisher = {Croatian Association for Cancer Research}, publisherplace = {Zagreb, Hrvatska} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus





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