engleski

Acute leukemia (AL) cytomorpholgy- basis for multidisciplinary diagnostic approach

1.20%BM blasts is basic for AL diagnosis. But, if cytogenetic abnormality such as t(8 ; 21) is found, number of blasts could be somewhat lower ; 2.5%BM blasts or less is criterion for morphologic remission of disease. However, <5% BM blasts with L3 or M3 morphology may point to minimal residual disease ; 4. cytomorphology and cytochemistry of BM and periferial blood (PB) should be done at diagnosis, if remission is not achived and relapse of disease ( possibility of blasts lineage switch) and 5. if there is no blasts in PB imunocytochemistry should be done for differentiation blasts from other undifferentiated malignant cells.

acute leukemia; cytomorphology

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