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Pregled bibliografske jedinice broj: 602475

Antiproliferative potency of novel benzofuran-2-carboxamides on tumor cell lines : cell death mechanisms and determination of crystal structure


Hranjec, Marijana; Sović, Irena; Ratkaj, Ivana; Pavlović, Gordana; Ilić, Nataša; Valjalo, Linda; Pavelić, Krešimir; Kraljević Pavelić, Sandra; Karminski-Zamola, Grace
Antiproliferative potency of novel benzofuran-2-carboxamides on tumor cell lines : cell death mechanisms and determination of crystal structure // European journal of medicinal chemistry, 59 (2013), 111-119 doi:10.1016/j.ejmech.2012.11.009 (međunarodna recenzija, članak, znanstveni)


Naslov
Antiproliferative potency of novel benzofuran-2-carboxamides on tumor cell lines : cell death mechanisms and determination of crystal structure

Autori
Hranjec, Marijana ; Sović, Irena ; Ratkaj, Ivana ; Pavlović, Gordana ; Ilić, Nataša ; Valjalo, Linda ; Pavelić, Krešimir ; Kraljević Pavelić, Sandra ; Karminski-Zamola, Grace

Izvornik
European journal of medicinal chemistry (0223-5234) 59 (2013); 111-119

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Benzofuranes; carboxamides; antiproliferative activity; apoptosis; crystal structure determination

Sažetak
In this manuscript the synthesis and biological activity of novel heterocyclic derivatives of benzofuran-2-carboxamides 3a-3j and 6a-6f is presented. Biological evaluation in vitro revealed that only few compounds exerted concentration-depended antiproliferative effects on tumour cell lines at micromolar concentrations. In particular, 2-imidazolynyl substituted compound 6f showed selectivity on SK-BR-3 cell line while 2-N-acetamidopyridyl substituted 3h and 2-imidazolynyl substituted amide 3i showed selective concentration-dependent antiproliferative effects on SW620 cell line. Compounds 3h and 6f induced apoptosis while compound 3i acted through a cell death mechanism other than apoptotis.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-1191344-2943 - Protein-ligand međudjelovanja na atomnoj razini (Marija Luić, )
125-0982464-1356 - Novi heterocikli kao antitumorski i antivirusni ("pametni") lijekovi (Marijana Hranjec, )
335-0000000-3532 - Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjeka (Sandra Kraljević Pavelić, )
335-0982464-2393 - Molekularna obilježja miofibroblasta Dupuytrenove bolesti (Krešimir Pavelić, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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