Antiproliferative potency of novel benzofuran-2-carboxamides on tumor cell lines: cell death mechanisms and determination of crystal structure (CROSBI ID 187583)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Hranjec, Marijana ; Sović, Irena ; Ratkaj, Ivana ; Pavlović, Gordana ; Ilić, Nataša ; Valjalo, Linda ; Pavelić, Krešimir ; Kraljević Pavelić, Sandra ; Karminski-Zamola, Grace
engleski
Antiproliferative potency of novel benzofuran-2-carboxamides on tumor cell lines: cell death mechanisms and determination of crystal structure
In this manuscript the synthesis and biological activity of novel heterocyclic derivatives of benzofuran-2-carboxamides 3a-3j and 6a-6f is presented. Biological evaluation in vitro revealed that only few compounds exerted concentration-depended antiproliferative effects on tumour cell lines at micromolar concentrations. In particular, 2-imidazolynyl substituted compound 6f showed selectivity on SK-BR-3 cell line while 2-N-acetamidopyridyl substituted 3h and 2-imidazolynyl substituted amide 3i showed selective concentration-dependent antiproliferative effects on SW620 cell line. Compounds 3h and 6f induced apoptosis while compound 3i acted through a cell death mechanism other than apoptotis.
benzofuranes ; carboxamides ; antiproliferative activity ; apoptosis ; crystal structure determination
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
59
2013.
111-119
objavljeno
0223-5234
1768-3254
10.1016/j.ejmech.2012.11.009
Povezanost rada
Kemija, Temeljne medicinske znanosti