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Antiproliferative potency of novel benzofuran-2-carboxamides on tumor cell lines: cell death mechanisms and determination of crystal structure (CROSBI ID 187583)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Hranjec, Marijana ; Sović, Irena ; Ratkaj, Ivana ; Pavlović, Gordana ; Ilić, Nataša ; Valjalo, Linda ; Pavelić, Krešimir ; Kraljević Pavelić, Sandra ; Karminski-Zamola, Grace Antiproliferative potency of novel benzofuran-2-carboxamides on tumor cell lines: cell death mechanisms and determination of crystal structure // European journal of medicinal chemistry, 59 (2013), 111-119. doi: 10.1016/j.ejmech.2012.11.009

Podaci o odgovornosti

Hranjec, Marijana ; Sović, Irena ; Ratkaj, Ivana ; Pavlović, Gordana ; Ilić, Nataša ; Valjalo, Linda ; Pavelić, Krešimir ; Kraljević Pavelić, Sandra ; Karminski-Zamola, Grace

engleski

Antiproliferative potency of novel benzofuran-2-carboxamides on tumor cell lines: cell death mechanisms and determination of crystal structure

In this manuscript the synthesis and biological activity of novel heterocyclic derivatives of benzofuran-2-carboxamides 3a-3j and 6a-6f is presented. Biological evaluation in vitro revealed that only few compounds exerted concentration-depended antiproliferative effects on tumour cell lines at micromolar concentrations. In particular, 2-imidazolynyl substituted compound 6f showed selectivity on SK-BR-3 cell line while 2-N-acetamidopyridyl substituted 3h and 2-imidazolynyl substituted amide 3i showed selective concentration-dependent antiproliferative effects on SW620 cell line. Compounds 3h and 6f induced apoptosis while compound 3i acted through a cell death mechanism other than apoptotis.

benzofuranes ; carboxamides ; antiproliferative activity ; apoptosis ; crystal structure determination

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Podaci o izdanju

59

2013.

111-119

objavljeno

0223-5234

1768-3254

10.1016/j.ejmech.2012.11.009

Povezanost rada

Kemija, Temeljne medicinske znanosti

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