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izvor podataka: crosbi

Chemokine CXCL10 at Week 4 of Treatment Predicts Sustained Virological Response in Patients with Chronic Hepatitis C (CROSBI ID 187120)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Kurelac, Ivan ; Židovec Lepej, Snježana ; Grgić, Ivana ; Gorenec, Lana ; Papić, Neven ; Dušek, Davorka ; Baršić, Bruno ; Vince, Adriana Chemokine CXCL10 at Week 4 of Treatment Predicts Sustained Virological Response in Patients with Chronic Hepatitis C // Journal of interferon & cytokine research, 32 (2012), 8; 386-391. doi: 10.1089/jir.2012.0006

Podaci o odgovornosti

Kurelac, Ivan ; Židovec Lepej, Snježana ; Grgić, Ivana ; Gorenec, Lana ; Papić, Neven ; Dušek, Davorka ; Baršić, Bruno ; Vince, Adriana

engleski

Chemokine CXCL10 at Week 4 of Treatment Predicts Sustained Virological Response in Patients with Chronic Hepatitis C

The aim of this study was to analyze the predictive value of CXCL9, CXCL10, and CXCL11 concentrations before and after 4 and 12 weeks of treatment with pegylated interferon-α2b and ribavirin in patients with chronic hepatitis C infected with the hepatitis C virus genotype 1. The study included 46 adult patients (29 women and 17 men). Chemokine quantification in the serum was performed at baseline and after 1, 3, and 6 months of treatment by enzyme immunoassay. Chemokine responses were compared in patients achieving a sustained virological response to treatment (SVR, n=26) and the non-SVR group (n=20). The differences in the CXCL9 and CXCL10 concentrations between the SVR and non-SVR groups were statistically significant. A multivariant analysis showed a significant association between treatment failure and higher concentrations of CXCL10. A higher predictive value of CXCL10 concentrations after 4 weeks of treatment compared to pretreatment values has been found (area under the curve 0.9288 and 0.7942, respectively, P=0.016). CXCL10 concentrations above 250 pg/mL 4 weeks after the start of treatment were independently associated with non-SVR. In conclusion, the results of this study have shown that CXCL10 concentrations at the time of a rapid viral response (4 weeks) are better predictors of achieving SVR compared to baseline levels. Additionally, this study suggests an important role of CXCL9 as a biomarker of SVR in patients with chronic hepatitis C.

CXCL10 ; CXCL11 ; CXCL9 ; HCV ; SVR ; interferon

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Podaci o izdanju

32 (8)

2012.

386-391

objavljeno

1079-9907

10.1089/jir.2012.0006

Povezanost rada

Kliničke medicinske znanosti

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