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Pregled bibliografske jedinice broj: 599247

GT microsatellite repeats in the heme oxygenase-1 gene promoter associated with abdominal aortic aneurysm in Croatian patients


Crkvenac Gregorek, Andrea; Crkvenac Gornik, Kristina; Stupin Polancec, Darija; Dabelić, Sanja
GT microsatellite repeats in the heme oxygenase-1 gene promoter associated with abdominal aortic aneurysm in Croatian patients // Biochemical genetics, 51 (2013), 5/6; 482-492 doi:10.1007/s10528-013-9579-8 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 599247 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
GT microsatellite repeats in the heme oxygenase-1 gene promoter associated with abdominal aortic aneurysm in Croatian patients

Autori
Crkvenac Gregorek, Andrea ; Crkvenac Gornik, Kristina ; Stupin Polancec, Darija ; Dabelić, Sanja

Izvornik
Biochemical genetics (0006-2928) 51 (2013), 5/6; 482-492

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
abdominal aortic aneurysm; heme oxygenase-1; gene polymorphism; GT microsatellite repeats

Sažetak
Abdominal aortic aneurysm (AAA) is a complex genetic disorder, caused by unfavorable interplay of different genetic and environmental risk factors. The number of (GT)n repeats in the heme oxygenase-1 (HO-1) gene promoter modulates transcription of this enzyme which might have anti-inflammatory, anti-oxidant, anti-apoptotic and anti-proliferative effect. Croatian individuals, genotyped for the first time for (GT)n HO-1 polymorphism, had similar distribution of alleles and genotypes as observed in other European populations. Higher frequency of the short (S) alleles (GT less than 25) was observed in AAA patients (41.9% vs 28.2%, p=0.0026) compared to non-AAA individuals, due to the higher frequency of heterozygotes SL (54.7% vs 35.9%, p=0.0058), but not homozygotes SS (14.5% vs 10.3%, p=0.4376). SL genotype (L more than 25 GT), more often found in AAA individuals, appeared to increase risk for AAA (OR=1.72, 95% CI=1.20-2.81, p=0.009 ; after adjustment for age, sex, smoking, hypertension and hyperlipidemia: OR=1.53, 95% CI=0.90-3.09, p=0.062). Taking into consideration that our findings are contradictory to the results of the only one study performed so far on the association of (GT)n HO-1 polymorphism and AAA, further investigations are needed to clarify this relationship.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Projekti:
006-0061194-1218 - Glikobiološki aspekti stanične prilagodbe i komunikacije (Dumić, Jerka, MZOS ) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

doi link.springer.com

Citiraj ovu publikaciju:

Crkvenac Gregorek, Andrea; Crkvenac Gornik, Kristina; Stupin Polancec, Darija; Dabelić, Sanja
GT microsatellite repeats in the heme oxygenase-1 gene promoter associated with abdominal aortic aneurysm in Croatian patients // Biochemical genetics, 51 (2013), 5/6; 482-492 doi:10.1007/s10528-013-9579-8 (međunarodna recenzija, članak, znanstveni)
Crkvenac Gregorek, A., Crkvenac Gornik, K., Stupin Polancec, D. & Dabelić, S. (2013) GT microsatellite repeats in the heme oxygenase-1 gene promoter associated with abdominal aortic aneurysm in Croatian patients. Biochemical genetics, 51 (5/6), 482-492 doi:10.1007/s10528-013-9579-8.
@article{article, author = {Crkvenac Gregorek, Andrea and Crkvenac Gornik, Kristina and Stupin Polancec, Darija and Dabeli\'{c}, Sanja}, year = {2013}, pages = {482-492}, DOI = {10.1007/s10528-013-9579-8}, keywords = {abdominal aortic aneurysm, heme oxygenase-1, gene polymorphism, GT microsatellite repeats}, journal = {Biochemical genetics}, doi = {10.1007/s10528-013-9579-8}, volume = {51}, number = {5/6}, issn = {0006-2928}, title = {GT microsatellite repeats in the heme oxygenase-1 gene promoter associated with abdominal aortic aneurysm in Croatian patients}, keyword = {abdominal aortic aneurysm, heme oxygenase-1, gene polymorphism, GT microsatellite repeats} }
@article{article, author = {Crkvenac Gregorek, Andrea and Crkvenac Gornik, Kristina and Stupin Polancec, Darija and Dabeli\'{c}, Sanja}, year = {2013}, pages = {482-492}, DOI = {10.1007/s10528-013-9579-8}, keywords = {abdominal aortic aneurysm, heme oxygenase-1, gene polymorphism, GT microsatellite repeats}, journal = {Biochemical genetics}, doi = {10.1007/s10528-013-9579-8}, volume = {51}, number = {5/6}, issn = {0006-2928}, title = {GT microsatellite repeats in the heme oxygenase-1 gene promoter associated with abdominal aortic aneurysm in Croatian patients}, keyword = {abdominal aortic aneurysm, heme oxygenase-1, gene polymorphism, GT microsatellite repeats} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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